ReviewBehaviour research and therapy2014
Elevated reward-related neural activation as a unique biological marker of bipolar disorder: assessment and treatment implications.
Review in Behaviour research and therapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Altered brain activation during reward anticipation in bipolar disorder.Translational psychiatry · 2022Pooled it
- Neural signatures of risk-taking adaptions across health, bipolar disorder, and lithium treatment.Molecular psychiatry · 2025Trial
- Neural correlates of citalopram and placebo response in acute bipolar depression: A randomized trial.Journal of psychiatric research · 2021Trial
- Lithium modulates striatal reward anticipation and prediction error coding in healthy volunteers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- How to study placebo responses in motion sickness with a rotation chair paradigm in healthy participants.Journal of visualized experiments : JoVE · 2014Trial
- Neural Markers of Reward Valuation and Impulsive Decision-Making in Mania Risk.JAMA psychiatry · 2026Article
- Elevated pre-supplementary motor area activity during reward expectancy: An impulsivity-related neural marker of vulnerability to bipolar and externalizing disorders.Molecular psychiatry · 2026Article
- Directional genetic relationships between obsessive-compulsive disorder and bipolar disorder and schizophrenia.medRxiv : the preprint server for health sciences · 2026Article
- Relationships of Cognitive Function With Subsequent Device-Measured Physical Activity and Sedentary Time in Healthy Individuals and Those With Bipolar Disorder: Findings From the UK Biobank.Acta psychiatrica Scandinavica · 2026Article
- Alteration of fronto-thalamic-striatal and visual network activity to positive emotional stimuli in adolescent patients with bipolar disorder during a Go/No-Go task-based functional brain MRI.NeuroImage. Clinical · 2026Article
- Long-Term Efficacy and Resting-State Functional Magnetic Resonance Imaging Changes of Deep Brain Stimulation in the Lateral Habenula Nucleus for Treatment-Resistant Bipolar Disorder.Brain and behavior · 2025Article
- Left Ventrolateral Prefrontal Cortical Activity During Reward Expectancy and Mania Risk.JAMA psychiatry · 2025Article
- The interaction network and potential clinical effectiveness of dimensional psychopathology phenotyping based on EMR: a Bayesian network approach.BMC psychiatry · 2025Article
- Article
- Neural markers of mania that distinguish inpatient adolescents with bipolar disorder from those with other psychopathology.Psychiatry research · 2024Article
- Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior.Journal of affective disorders · 2024Article
- Utilizing systematic Mendelian randomization to identify potential therapeutic targets for mania.Frontiers in psychiatry · 2024Article
- Hippocampal subfield morphology from first episodes of bipolar disorder type II and major depressive disorder in a drug naïve Chinese cohort.Frontiers in psychiatry · 2024Article
- Advances in functional MRI research in bipolar disorder: from the perspective of mood states.General psychiatry · 2024Review
- Cumulative lifetime acute stressor exposure interacts with reward responsiveness to predict longitudinal increases in depression severity in adolescence.Psychological medicine · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Growing evidence indicates that risk for bipolar disorder is characterized by elevated activation in a fronto-striatal reward neural circuit involving the ventral striatum and orbitofrontal cortex, among other regions. It is proposed that individuals with abnormally elevated reward-related neural activation are at risk for experiencing an excessive increase in approach-related motivation during life events involving rewards or goal striving and attainment. In the extreme, this increase in motivation is reflected in hypomanic/manic symptoms. By contrast, unipolar depression (without a history of hypomania/mania) is characterized by decreased reward responsivity and decreased reward-related neural activation. Collectively, this suggests that risk for bipolar disorder and unipolar depression are characterized by distinct and opposite profiles of reward processing and reward-related neural activation. The objective of the present paper is threefold. First, we review the literature on reward processing and reward-related neural activation in bipolar disorder, and in particular risk for hypomania/mania. Second, we propose that reward-related neural activation reflects a biological marker of differential risk for bipolar disorder versus unipolar depression that may help facilitate psychiatric assessment and differential diagnosis. We also discuss, however, the challenges to using neuroscience techniques and biological markers in a clinical setting for assessment and diagnostic purposes. Lastly, we address the pharmacological and psychosocial treatment implications of research on reward-related neural activation in bipolar disorder.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.