Evidence map›Paper›PMID 25241182›Full record

ArticleThe Journal of pediatrics2014

Parental military service, agent orange exposure, and the risk of rhabdomyosarcoma in offspring.

Seymour Grufferman, Philip J Lupo, Rachel Isaksson Vogel, Heather E Danysh, Erik B Erhardt, Simona Ognjanovic

Open access · greenAbstract readHistorical Article
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of pediatrics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Rhabdomyosarcoma.Nature reviews. Disease primers · 2019
    Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 1 country.

Seymour GruffermanDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM.
Philip J LupoDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX. Electronic address: Philip.Lupo@bcm.edu.
Rachel Isaksson VogelMasonic Cancer Center, University of Minnesota, Minneapolis, MN.
Heather E DanyshDepartment of Pediatrics, Section of Hematology-Oncology, Texas Children's Cancer Center, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX.
Erik B ErhardtDepartment of Mathematics and Statistics, University of New Mexico, Albuquerque, NM.
Simona OgnjanovicMayo Graduate School, Mayo Clinic, Rochester, MN.
Children's Cancer Center · USUniversity of New Mexico · USMayo Clinic · USUniversity of Minnesota · US

Funding

PEDIATRIC ONCOLOGY GROUP STATISTICAL OFFICEU10CA029139 · NCI · UNIVERSITY OF FLORIDA · PI DEVIDAS, MEENAKSHI · 1985 to 2002
$7.3M
INTERGROUP RHABDOMYOSARCOMA STUDYU10CA024507 · NCI · VIRGINIA COMMONWEALTH UNIVERSITY · PI REAMAN, GREGORY H · 1985 to 2002
$2.0M
NCI NIH HHS U10 CA024507NCI NIH HHS U10 CA029139NIDCR NIH HHS L40 DE023736
6 · The paper itself

Abstract

objectiveTo evaluate the role of parental military service-related exposures and rhabdomyosarcoma (RMS) risk in offspring using data from a large case-control study of childhood RMS. STUDY

designCases (n = 319) were enrolled from the third trial run by the Intergroup Rhabdomyosarcoma Study Group. Population-based controls (n = 319) were pair-matched to cases on race, sex, and age. Conditional logistic regression was used to evaluate parental military service-related exposures and their associations with childhood RMS by generating aORs and 95% CIs. Statistical significance was defined as P < .05.

resultsThere were no significant associations between parental military service and childhood RMS. The strongest association was with maternal military service; however, this association was attenuated and did not remain significant after adjusting for covariates (aOR = 2.75, 95% CI 0.71, 10.62). An elevated effect estimate was found when assessing paternal exposure to Agent Orange (AO) and childhood RMS but was not statistically significant (aOR = 1.72, 95% CI 0.55, 5.41).

conclusionsWe found little evidence that parental military service of AO exposure influences the risk of RMS in offspring. These findings are notable in light of the continuing controversies surrounding the intergenerational effects of AO exposure.

Indexed as

Military PersonnelVietnam Conflict2,4,5-Trichlorophenoxyacetic Acid2,4-Dichlorophenoxyacetic AcidAdultAgent OrangeCase-Control StudiesChildDefoliants, ChemicalEnvironmental ExposureFemaleHistory, AncientHumansMaleMaternal ExposureParents2,4,5-Trichlorophenoxyacetic Acid2,4-Dichlorophenoxyacetic AcidAgent OrangeDefoliants, ChemicalPolychlorinated Dibenzodioxins

Identifiers

PMID25241182
PMCPMC4254119
OpenAlexW2064653674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.