ArticleBMC complementary and alternative medicine2014
Antibacterial effect of crude extract and metabolites of Phytolacca americana on pathogens responsible for periodontal inflammatory diseases and dental caries.
Article in BMC complementary and alternative medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 67 citations in OpenAlex.
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- Natural compounds: new therapeutic approach for inhibition ofFrontiers in pharmacology · 2025Review
- Exploring the therapeutic potential of medicinal plants and their active principles in dental care: A comprehensive review.Heliyon · 2024Review
- Herbal Metabolites as Potential Carbonic Anhydrase Inhibitors: Promising Compounds for Cancer and Metabolic Disorders.Journal of obesity & metabolic syndrome · 2023Article
- Analysis of Antibiofilm Activities of Bioactive Compounds from Honeyweed (Leonurus sibiricus) Against P. aeruginosa: an In Vitro and In Silico Approach.Applied biochemistry and biotechnology · 2023Article
- Biogenic silver nanoparticles (AgNPs) fromFrontiers in chemistry · 2023Article
- Therapeutic Potential of Flavonoids and Tannins in Management of Oral Infectious Diseases-A Review.Molecules (Basel, Switzerland) · 2022Review
- Selective Inhibition of the Periodontal PathogenJournal of medicinal chemistry · 2022Article
- Using of Essential Oils and Plant Extracts againstPlants (Basel, Switzerland) · 2022Article
- Review
- HPLC Quantification of Thymoquinone Extracted fromEvidence-based complementary and alternative medicine : eCAM · 2021Article
- The Porphyromonas gingivalis inhibitory effects, antioxidant effects and the safety of a Sri Lankan traditional betel quid - an in vitro study.BMC complementary medicine and therapies · 2020Article
- Invasive Plants: Turning Enemies into Value.Molecules (Basel, Switzerland) · 2020Review
- Edible Leafy Plants from Mexico as Sources of Antioxidant Compounds, and Their Nutritional, Nutraceutical and Antimicrobial Potential: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- In Vitro Effect of the Traditional Medicine Hainosan (Painongsan) onMedicines (Basel, Switzerland) · 2019Article
- Egg yolk immunoglobulin interactions with Porphyromonas gingivalis to impact periodontal inflammation and halitosis.AMB Express · 2018Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe oral cavity is the store house of different species of microorganisms that are continuously engaged in causing diseases in the mouth. The present study was conducted to evaluate the antibacterial potential of crude extracts of the aerial parts of Phytolacca americana and its natural compounds against two oral pathogens, Porphyromonas gingivalis and Streptococcus mutans, which are primarily responsible for periodontal inflammatory diseases and dental caries, as well as a nonpathogenic Escherichia coli.
methodsCrude extract and fractions from the aerial parts of P. americana (0.008-1.8 mg/mL) were evaluated for their potential antibacterial activity against two oral disease causing microorganisms by micro-assays. The standard natural compounds present in P. americana, kaempferol, quercetin, quercetin 3-glucoside, isoqueritrin and ferulic acid, were also tested for their antibacterial activity against the pathogens at 1-8 μg/mL.
resultsThe crude extract was highly active against P. gingivalis (100% growth inhibition) and moderately active against S. mutans (44% growth inhibition) at 1.8 mg/mL. The chloroform and hexane fraction controlled the growth of P. gingivalis with 91% and 92% growth inhibition at a concentration of 0.2 mg/mL, respectively. Kaempferol exerted antibacterial activity against both the pathogens, whereas quercetin showed potent growth inhibition activity against only S. mutans in a concentration dependent manner.
conclusionThe crude extract, chloroform fraction, and hexane fraction of P. americana possesses active natural compounds that can inhibit the growth of oral disease causing bacteria. Thus, these extracts have the potential for use in the preparation of toothpaste and other drugs related to various oral diseases.
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