Evidence map›Paper›PMID 25240686›Full record

ReviewCurrent rheumatology reports2014

The nature of in vivo mechanical signals that influence cartilage health and progression to knee osteoarthritis.

Thomas P Andriacchi, Julien Favre

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current rheumatology reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Step-by-step insight into gait analysis: A narrative review unlocking knee biomechanics.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2026
    Review
  8. Article
  9. Article
  10. Programmed cell death in osteoarthritis.Apoptosis : an international journal on programmed cell death · 2026
    Review
  11. Review
  12. Article
  13. Therapeutic Footwear for Medial Knee Osteoarthritis: Individualizing Midsole Stiffness Enhances Intended Kinetic Changes.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2026
    Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Thomas P AndriacchiDepartment of Mechanical Engineering, Stanford University, Durand 227, Stanford, CA, 94305, USA, tandriac@stanford.edu.
Julien Favre

Funding

Knee Implant Wear Evaluation-An Integrated ApproachR01AR049793 · NIAMS · HOSPITAL FOR SPECIAL SURGERY · PI WRIGHT, TIMOTHY M · 2003 to 2005
$928k
NIAMS NIH HHS AR049793
6 · The paper itself

Abstract

Knee osteoarthritis is a disease that can be initiated along multiple pathways that ultimately leads to pain, loss of function and breakdown of the articular cartilage. While the various pathways have biological and structural elements, the mechanical pathways play a critical role in the development of the disease. The forces and motions occurring during ambulation provide mechanical signals sensed at the scale of the cell that are critical to healthy joint homeostasis. As such, ambulatory changes associated with aging, obesity, or joint injury that occur prior to the development of symptoms of OA can ultimately lead to clinical OA. Conversely, inter-scale signaling (e.g., pain) generated by biological changes in the early stages of OA can produce adaptive ambulatory changes that can modify the rate of OA progression. Thus, the nature of the physical and clinical response to the mechanical signals that occur during ambulation is critical to understanding the etiology of osteoarthritis.

Indexed as

Cartilage, ArticularHumansOsteoarthritis, KneeRange of Motion, ArticularStress, MechanicalWalkingWeight-Bearing

Identifiers

PMID25240686

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.