ReviewJACC. Cardiovascular interventions2014
Methodological standardization for the pre-clinical evaluation of renal sympathetic denervation.
Review in JACC. Cardiovascular interventions, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 76 citations in OpenAlex.
- Paclitaxel-coated balloon treatment is associated with sympathetic coronary denervation in a porcine model.Scientific reports · 2026Article
- A novel laparoscopic renal denervation system in a preclinical swine model.Scientific reports · 2026Article
- Renal denervation improves cardiac function and exercise duration in a miniswine model of heart failure with preserved ejection fraction.European journal of heart failure · 2025Article
- Renal Denervation After USA FDA Approval: An Update from an Interventional Cardiologist's Perspective.Journal of clinical medicine · 2025Review
- Preclinical Evaluation of a Novel Cryo Renal Denervation System.JACC. Basic to translational science · 2025Article
- Multiphoton Microscopy to Visualize Live Renal Nerves in Reanimated Kidney Blocks.Journal of imaging · 2025Article
- Pulmonary artery denervation by noninvasive stereotactic radiotherapy: a pilot study in swine models of pulmonary hypertension.Nature communications · 2025Article
- Article
- Stereotactic body radiotherapy: a new non-invasive way to conduct pulmonary artery denervation.Frontiers in medicine · 2025Article
- High-intensity Focused Ultrasound-A New Choice to Conduct Pulmonary Artery Denervation.Journal of cardiovascular translational research · 2024Article
- Long-Term Safety and Efficacy of Transcatheter Microwave and Radiofrequency Denervation in a Chronic Ovine Model.Journal of the American Heart Association · 2024Article
- Translational value of preclinical models for renal denervation: a histological comparison of human versus porcine renal nerve anatomy.EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology · 2023Article
- A drug-induced hypotensive challenge to verify catheter-based radiofrequency renal denervation in an obese hypertensive swine model.Clinical research in cardiology : official journal of the German Cardiac Society · 2022Article
- [Renal sympathetic denervation can significantly reduce blood pressure and improve arterial stiffness in hypertensive beagles].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2021Article
- Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model.Journal of the American Heart Association · 2021Article
- Renal Denervation Attenuates Neuroinflammation in the Brain by Regulating Gut-Brain Axis in Rats With Myocardial Infarction.Frontiers in cardiovascular medicine · 2021Article
- Optimal Strategy for HIFU-Based Renal Sympathetic Denervation in Canines.Frontiers in cardiovascular medicine · 2021Article
- Development and Evaluation of a Disease Large Animal Model for Preclinical Assessment of Renal Denervation Therapies.Animals : an open access journal from MDPI · 2020Article
- Morphological evaluation of sympathetic renal innervation in patients with autosomal dominant polycystic kidney disease.Journal of nephrology · 2020Article
- Effect of Renal Denervation on Suppression of PVC and QT Prolongation in a Porcine Model of Acute Myocardial Infarction.Korean circulation journal · 2020Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Transcatheter ablation of renal autonomic nerves is a viable option for the treatment of resistant arterial hypertension; however, structured pre-clinical evaluation with standardization of analytical procedures remains a clear gap in this field. Here we discuss the topics relevant to the pre-clinical model for the evaluation of renal denervation (RDN) devices and report methodologies and criteria toward standardization of the safety and efficacy assessment, including histopathological evaluations of the renal artery, periarterial nerves, and associated periadventitial tissues. The pre-clinical swine renal artery model can be used effectively to assess both the safety and efficacy of RDN technologies. Assessment of the efficacy of RDN modalities primarily focuses on the determination of the depth of penetration of treatment-related injury (e.g., necrosis) of the periarterial tissues and its relationship (i.e., location and distance) and the effect on the associated renal nerves and the correlation thereof with proxy biomarkers including renal norepinephrine concentrations and nerve-specific immunohistochemical stains (e.g., tyrosine hydroxylase). The safety evaluation of RDN technologies involves assessing for adverse effects on tissues local to the site of treatment (i.e., on the arterial wall) as well as tissues at a distance (e.g., soft tissue, veins, arterial branches, skeletal muscle, adrenal gland, ureters). Increasing experience will help to create a standardized means of examining all arterial beds subject to ablative energy and in doing so enable us to proceed to optimize the development and assessment of these emerging technologies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.