ReviewMolecular and cellular endocrinology2015
Understanding primary aldosteronism: impact of next generation sequencing and expression profiling.
Review in Molecular and cellular endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- Proportion of Patients With Hypertension Resolution Following Adrenalectomy for Primary Aldosteronism: A Systematic Review and Meta-Analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2016Pooled it
- Prevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population.Scientific reports · 2015Trial
- Diagnosis and Treatment of Monogenic Hypertension in Children.Yonsei medical journal · 2023Review
- [Immunogenetics of primary hyperaldosteronism: fundamental studies and their clinical prospects].Problemy endokrinologii · 2022Article
- Unravelling the Genetic Basis of Primary Aldosteronism.Nutrients · 2021Review
- The Bioinformatics Analysis of Aldosterone-Producing Adenoma and Verification of Differentially Expressed Genes.International journal of endocrinology · 2021Article
- Somatic mutations in adrenocortical carcinoma with primary aldosteronism or hyperreninemic hyperaldosteronism.Endocrine-related cancer · 2019Article
- Role of Cryptochrome-1 and Cryptochrome-2 in Aldosterone-Producing Adenomas and Adrenocortical Cells.International journal of molecular sciences · 2018Article
- Aging and Adrenal Aldosterone Production.Hypertension (Dallas, Tex. : 1979) · 2018Review
- The Many Faces of Primary Aldosteronism and Cushing Syndrome: A Reflection of Adrenocortical Tumor Heterogeneity.Frontiers in medicine · 2018Review
- Familial hyperaldosteronism type III.Journal of human hypertension · 2017Review
- Article
- Is There a Role for Genomics in the Management of Hypertension?International journal of molecular sciences · 2017Review
- The Future of "Omics" in Hypertension.The Canadian journal of cardiology · 2017Review
- Hyperaldosteronism: How to Discriminate Among Different Disease Forms?High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Review
- Issues in the Diagnosis and Treatment of Primary Aldosteronism.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Review
- Hyperaldosteronism: Screening and Diagnostic Tests.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2016Review
- ARMC5 mutation analysis in patients with primary aldosteronism and bilateral adrenal lesions.Journal of human hypertension · 2016Article
- Molecular Heterogeneity in Aldosterone-Producing Adenomas.The Journal of clinical endocrinology and metabolism · 2016Article
- Personalized Therapy of Hypertension: the Past and the Future.Current hypertension reports · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Primary aldosteronism (PA) encompasses a broad, heterogeneous group of disorders including both sporadic and familial forms (familial hyperaldosteronism type I, II and III). PA is the most common form of secondary hypertension and associated with a higher rate of cardiovascular complications, compared with essential hypertension. Despite significant progress in the diagnosis and management of PA, until recently the molecular mechanisms leading to inappropriate aldosterone production were largely unknown. The introduction of next-generation sequencing has had a profound impact on the field of human genetics and has given new insight in the molecular determinants that lead to both sporadic and familial forms of PA. Here we review the recent progress toward understanding of the genetic and molecular mechanisms leading to autonomous aldosterone production in PA.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.