ArticleMolecular and cellular biochemistry2015
Dynamics of telopodes (telocyte prolongations) in cell culture depends on extracellular matrix protein.
Article in Molecular and cellular biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- An Enriched Primary Culture Reveals Morphological Heterogeneity of Rat Testicular Telocytes.Cells · 2026Article
- Elucidating the preventive and therapeutic effects of cardiac telocytes paracrine microRNAs on ischemic heart disease.Frontiers in cardiovascular medicine · 2025Article
- Telocytes: current methods of research, challenges and future perspectives.Cell and tissue research · 2024Review
- Telocytes of the male reproductive system: dynamic tissue organizers.Frontiers in cell and developmental biology · 2024Review
- Telocytes: Active Players in the Rainbow Trout (Animals : an open access journal from MDPI · 2021Article
- Article
- Morpho-functional changes of cardiac telocytes in isolated atrial amyloidosis in patients with atrial fibrillation.Scientific reports · 2021Article
- Identification of CD34+/PGDFRα+ Valve Interstitial Cells (VICs) in Human Aortic Valves: Association of Their Abundance, Morphology and Spatial Organization with Early Calcific Remodeling.International journal of molecular sciences · 2020Article
- An in vitro investigation of telocytes-educated macrophages: morphology, heterocellular junctions, apoptosis and invasion analysis.Journal of translational medicine · 2018Article
- Telocytes in female reproductive system (human and animal).Journal of cellular and molecular medicine · 2016Review
- Reaching out: junctions between cardiac telocytes and cardiac stem cells in culture.Journal of cellular and molecular medicine · 2016Article
- Telopodes of telocytes are influenced in vitro by redox conditions and ageing.Molecular and cellular biochemistry · 2015Article
- The failing human heart is characterized by decreased numbers of telocytes as result of apoptosis and altered extracellular matrix composition.Journal of cellular and molecular medicine · 2015Article
- Cardiac telocytes are double positive for CD34/PDGFR-α.Journal of cellular and molecular medicine · 2015Article
- The secretome of myocardial telocytes modulates the activity of cardiac stem cells.Journal of cellular and molecular medicine · 2015Article
- Ultrastructure damage of oviduct telocytes in rat model of acute salpingitis.Journal of cellular and molecular medicine · 2015Article
- Telocytes in regenerative medicine.Journal of cellular and molecular medicine · 2015Review
- Telocyte dynamics in psoriasis.Journal of cellular and molecular medicine · 2015Article
- Telocytes in minor salivary glands of primary Sjögren's syndrome: association with the extent of inflammation and ectopic lymphoid neogenesis.Journal of cellular and molecular medicine · 2015Article
- FIB-SEM tomography of human skin telocytes and their extracellular vesicles.Journal of cellular and molecular medicine · 2015Article
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8 authors.
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Abstract
Telocytes (TC) are cells with telopodes (Tp), very long prolongations (up to 100 μm) with an uneven caliber ( www.telocytes.com ). Factors determining the dynamics of cellular prolongations are still unknown, although previous studies showed telopode motility in TC cultures. We comparatively investigated, by time-lapse videomicroscopy, the dynamics of Tp of mouse heart TC seeded on collagen, fibronectin, and laminin. Under our experimental conditions, TC and fibroblasts (cell line L929) behaved differently in terms of adherence, spreading, and prolongation extension. Fibroblasts showed lower spreading on the matrix proteins used. The time needed for spreading was 2-4 h for TC, versus 8-10 h for fibroblasts. The values for final cell surface area after spreading were between 200 and 400 μm(2) for fibroblasts and 800-2,000 μm(2) for TC. TC showed a more than three times higher ability to spread on the tested matrix proteins. An extremely low capacity to extend prolongations with lengths shorter than cell bodies was noted for fibroblasts, while TC extended prolongations longer than the cell body length, with a moniliform appearance. The stronger adherence and spreading were noted for TC seeded on fibronectin, while the lowest were on laminin. Collagen determined an intermediate adherence and spreading for TC, but the highest dynamics in Tp extensions. In conclusion, TC behave differently than fibroblasts in terms of adherence, spreading, and cell prolongation extension when seeded on various matrix proteins in cell culture.
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