Trial reportLasers in medical science2015
Low-level laser therapy as an alternative for pulpotomy in human primary teeth.
Trial report in Lasers in medical science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Efficacy and safety of diode laser in pulpotomy: a systematic review and meta-analysis.BMC oral health · 2026Pooled it
- Laser pulpotomy-an effective alternative to conventional techniques-a systematic review of literature and meta-analysis.Lasers in medical science · 2018Pooled it
- Clinical and radiographic outcomes of laser pulpotomy in vital primary teeth: a systematic review and meta-analysis.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2018Pooled it
- Clinical and radiographic effectiveness of mineral trioxide aggregate (MTA) partial pulpotomy with low power or high power diode laser irradiation in deciduous molars: a randomized clinical trial.Lasers in medical science · 2022Trial
- Comparison between calcium hydroxide mixtures and mineral trioxide aggregate in primary teeth pulpotomy: a randomized controlled trial.Journal of applied oral science : revista FOB · 2019Trial
- Effectiveness of Diode Lasers as an Adjunct in Pulpotomy Procedures Involving Primary Teeth: A Systematic Review.International journal of clinical pediatric dentistry · 2025Article
- A preliminary study on the effect of photobiomodulation with diode laser on direct pulp capping of cariously exposed teeth.Journal of conservative dentistry and endodontics · 2025Article
- Clinical and Radiographic Efficacy of Low-level Laser Therapy and Formocresol as Pulpotomy Agents in Primary Molars: A Systematic Review and Meta-analysis.International journal of clinical pediatric dentistry · 2024Article
- Histological Evaluation of Photobiomodulation and Calcium Aluminosilicate on Direct Pulp Capping of Dogs' Permanent Teeth.Journal of lasers in medical sciences · 2024Article
- The application of lasers in vital pulp therapy: a review of histological effects.Lasers in medical science · 2023Review
- Dentists' Self-evaluated Ability in Diagnosing and Updating About Pulpotomy.International dental journal · 2023Article
- Photobiomodulation effect of red LED (630 nm) on the free radical levels produced by pulp cells under stress conditions.Lasers in medical science · 2022Article
- Photobiomodulation reduces inflammation but does not influence the hypoxia-inducible factor-1α in pulp tissue of rats after bleaching.Journal of applied oral science : revista FOB · 2022Article
- Could the photobiomodulation therapy induce angiogenic growth factors expression from dental pulp cells?Lasers in medical science · 2021Article
- Photobiomodulation effect on angiogenic proteins produced and released by dental pulp cells.Clinical oral investigations · 2020Article
- Article
- Outcome comparison between diode laser pulpotomy and formocresol pulpotomy on human primary molars.Journal of dental sciences · 2020Article
- Effect of single and multiple doses of low-level laser therapy on viability and proliferation of stem cells from human exfoliated deciduous teeth (SHED).Lasers in medical science · 2019Article
- Low-level laser therapy affects dentinogenesis and angiogenesis of in vitro 3D cultures of dentin-pulp complex.Lasers in medical science · 2019Article
- Comparative evaluation of clinical outcome of indirect pulp treatment with calcium hydroxide, calcium silicate and Er,Cr:YSGG laser in permanent molars.Laser therapy · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the effects of low-level laser therapy (LLLT) on pulpal response of primary teeth. Twenty mandibular primary molars were randomly divided into the following groups: group I Buckley's formocresol (diluted at 1:5), group II calcium hydroxide, group III LLLT + zinc oxide/eugenol, and group IV LLLT + calcium hydroxide. LLLT parameters were set at 660-nm wavelength, 10-mW power output, and 2.5 J/cm(2) energy density for 10 s in continuous mode (InGaAlP laser, Twin Laser®, MMOptics, Sao Carlos, Sao Paulo, Brazil). The teeth were extracted at the regular exfoliation period. The dentin-pulp complex was graded by an established histopathological score system. Statistical analysis was performed by Kruskal-Wallis and chi-square test. The histopathological assessment revealed statistically significant differences among groups (P < 0.05). The lowest degree of pulpal inflammation was present in LLLT + calcium hydroxide (P = 0.0296). Calcium hydroxide showed the highest rate of hard tissue barrier (P = 0.0033), odontoblastic layer (P = 0.0033), and dense collagen fibers (P = 0.0095). On the other hand, formocresol showed the highest incidence of internal resorption (P = 0.0142). Based on this study, low-level laser therapy preceding the use of calcium hydroxide exhibited satisfactory results on pulp tissue healing. However, further clinical studies on human teeth with long-term follow-up are needed to test the low-level laser therapy efficacy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.