Evidence map›Paper›PMID 25240055›Full record

ArticleJournal of the American Heart Association2014

Gastrointestinal intervention ameliorates high blood pressure through antagonizing overdrive of the sympathetic nerve in hypertensive patients and rats.

Hexuan Zhang, Yunfei Pu, Jing Chen, Weidong Tong, Yuanting Cui, Fang Sun, Zhou Zheng, Qiang Li, Tao Yang, Changyuan Meng and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  4. Review
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  8. Article
  9. Article
  10. Obesity, Hypertension, and Bariatric Surgery.Current hypertension reports · 2020
    Review
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  14. Article
  15. Article
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  17. Article
  18. Article
  19. The Role of Metabolic Surgery on Blood Pressure Control.Current atherosclerosis reports · 2016
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hexuan ZhangCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Yunfei PuCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Jing ChenCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Weidong TongDepartment of General Surgery, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing, China (W.T.).
Yuanting CuiCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Fang SunCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Zhou ZhengCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Qiang LiCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Tao YangCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Changyuan MengCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Zongshi LuCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Li LiCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Zhencheng YanCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Daoyan LiuCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).
Zhiming ZhuCenter for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China (H.Z., Y.P., J.C., Y.C., F.S., Z.Z., Q.L., T.Y., C.M., Z.L., L.L., Z.Y., D.L., Z.Z.).

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWe investigated the hypothesis that the favorable effects of gastrointestinal (GI) intervention on hypertension (HTN) and cardiovascular (CV) disturbances are mediated by antagonizing overdrive of the sympathetic nervous system (SNS). METHODS AND

resultsHypertensive patients with metabolic disturbances underwent laparoscopic Roux-en-Y gastric bypass surgery, and spontaneously hypertensive rats (SHRs) underwent RYGB or sham surgery. Blood pressure (BP), heart rate (HR), endothelium-dependent flow-mediated dilation, and anthropometric as well as laboratory parameters were measured at baseline and during follow-up. Changes of BP and HR in response to cold stress, renal sympathetic nervous activity (RSNA), vasoconstriction induced by electrical field stimulation, microinjection of nucleus of the solitary tract (NTS), and CV function and structure were examined in SHRs with or without surgery. Compared with baseline, BP and HR were significantly reduced in both hypertensive patients with type 2 diabetes and rats. Impaired endothelial-dependent vasodilatation and metabolic disturbances in hypertensive patients were also ameliorated after surgery. CV disturbances were reversed by surgery in SHRs. Under acute cold exposure, the variations in BP and HR were smaller in surgically treated SHRs, compared to sham SHRs. RSNA and vasoconstriction induced by perivascular nerve stimulation as well as NTS-mediated changes of BP were decreased in surgically treated SHRs, compared to sham SHR. Weight loss did not affect BP and RSNA in sham SHRs.

conclusionsGI intervention ameliorates HTN in both hypertensive patients and rats by inhibiting overdrive of the SNS. Therefore, targeting gastrointestine could be a novel strategy to treat HTN with metabolic disturbances.

Indexed as

Blood PressureLaparoscopyAdultAnimalsBiomarkersCardiovascular SystemCold-Shock ResponseDiabetes Mellitus, Type 2Disease Models, AnimalElectric StimulationEndothelium, VascularFemalegamma-Aminobutyric AcidGastric BypassHeart RateHumansBiomarkersgamma-Aminobutyric Acidgastric bypass surgerygastrointestinal interventionhypertensionsympathetic nervous system

Identifiers

PMID25240055
PMCPMC4323786

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.