ArticleChemical senses2014
Gray matter volume reduction of olfactory cortices in patients with idiopathic olfactory loss.
Article in Chemical senses, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Does Olfactory Training Improve Brain Function and Cognition? A Systematic Review.Neuropsychology review · 2024Pooled it
- A systematic review of olfactory-related brain structural changes in patients with congenital or acquired anosmia.Brain structure & function · 2022Pooled it
- Aroma of Genius Essential Oil Blend Significantly Enhances Cognitive Performance and Brain Metabolism in Healthy Adults.Human psychopharmacology · 2025Trial
- Characteristics of subjective olfactory dysfunction and imaging features in patients with traumatic olfactory disorders: a retrospective case-control study.Quantitative imaging in medicine and surgery · 2024Article
- Lifelong olfactory deprivation-dependent cortical reorganization restricted to orbitofrontal cortex.Human brain mapping · 2023Article
- Overnight olfactory enrichment using an odorant diffuser improves memory and modifies the uncinate fasciculus in older adults.Frontiers in neuroscience · 2023Review
- Functional septorhinoplasty alters brain structure and function: Neuroanatomical correlates of olfactory dysfunction.Frontiers in allergy · 2023Article
- [Analysis of clinical characteristics in the patient with olfactory disorders].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2022Article
- International consensus statement on allergy and rhinology: Olfaction.International forum of allergy & rhinology · 2022Review
- Olfactory loss is a predisposing factor for depression, while olfactory enrichment is an effective treatment for depression.Frontiers in neuroscience · 2022Article
- Patterns of Gray and White Matter Volume Alterations in Patients With Post-Traumatic Anosmia: A Voxel-Based Morphometry Study.Frontiers in neurology · 2022Article
- Brain Structure as a Correlate of Odor Identification and Cognition in Type 2 Diabetes.Frontiers in human neuroscience · 2022Article
- Odor Identification and Regional Gray Matter Atrophy in Patients with Alzheimer's Disease, Parkinson's Disease, and the Healthy Elderly: A Cross-Sectional Structural MRI Study.Brain sciences · 2021Article
- Acquired olfactory loss alters functional connectivity and morphology.Scientific reports · 2021Article
- Investigating morphological changes in the brain in relation to etiology and duration of olfactory dysfunction with voxel-based morphometry.Scientific reports · 2021Article
- Insula and Olfaction: A Literature Review and Case Report.Brain sciences · 2021Article
- Altered grey matter volume in 'super smellers'.Brain imaging and behavior · 2019Article
- Evaluation of idiopathic olfactory loss with chemosensory event-related potentials and magnetic resonance imaging.International forum of allergy & rhinology · 2018Article
- Environmental Enrichment and Successful Aging.Frontiers in behavioral neuroscience · 2018Review
- Anosmia-A Clinical Review.Chemical senses · 2017Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Idiopathic olfactory loss (IOL) is a common olfactory disorder. Little is known about the pathophysiology of this disease. Previous studies demonstrated decreased olfactory bulb (OB) volume in IOL patients when compared with controls. The aim of our study was to investigate structural brain alterations in areas beyond the OB. We acquired T1-weighted magnetic resonance images from 16 patients with IOL and from 16 age- and sex-matched controls on a 3T scanner. Voxel-based morphometry (VBM) was performed using VBM8 toolbox and SPM8 in a Matlab environment. Psychophysical testing confirmed that patients had higher scores for Toyota and Takagi olfactometer and lower scores for Sniffin' Sticks olfactory test than controls (t = 46.9, P < 0.001 and t = 21.4, P < 0.001, respectively), consistent with olfactory dysfunction. There was a significant negative correlation between the 2 olfactory tests (r = -0.6, P = 0.01). In a volume of interest analysis including primary and secondary olfactory areas, we found patients with IOL to exhibit gray matter volume loss in the orbitofrontal cortex, anterior cingulate cortex, insular cortex, parahippocampal cortex, and the piriform cortex. The present study indicates that changes in the central brain structures proximal to the OB occur in IOL. Further investigations of this phenomenon may be helpful to elucidate the etiology of IOL.
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