ArticleApplied and environmental microbiology2014
Prebiotic Oligosaccharides: Comparative Evaluation Using In Vitro Cultures of Infants' Fecal Microbiomes.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Bioengineering Interventions to Enhance the Capacity of the Gut Microbiota in Controlling Food Allergies.Life (Basel, Switzerland) · 2026Review
- Structural Characterization of Disaccharides Using Cyclic Ion Mobility Spectrometry and Monosaccharide Standards.Journal of the American Society for Mass Spectrometry · 2024Article
- Gram-scale chemical synthesis of galactosyllactoses and their impact on infant gut microbiotaOrganic & biomolecular chemistry · 2024Article
- Effects of SynbioticFoods (Basel, Switzerland) · 2023Article
- Infant Fecal Fermentations with Galacto-Oligosaccharides and 2'-Fucosyllactose Show DifferentialChildren (Basel, Switzerland) · 2023Article
- Complementary Food Ingredients Alter Infant Gut Microbiome Composition and Metabolism In Vitro.Microorganisms · 2021Article
- The sugar composition of the fibre in selected plant foods modulates weaning infants' gut microbiome composition and fermentation metabolites in vitro.Scientific reports · 2021Article
- Oligosaccharides and Complex Carbohydrates: A New Paradigm for Cranberry Bioactivity.Molecules (Basel, Switzerland) · 2020Review
- Article
- The Magnesium-Rich Formula for Functional Constipation in Infants: a Randomized Comparator-Controlled Study.Pediatric gastroenterology, hepatology & nutrition · 2019Article
- Infant food applications of complex carbohydrates: Structure, synthesis, and function.Carbohydrate research · 2017Review
- High-Fat Diet, Dysbiosis, and Gastrointestinal and Colonic Transit: Is There a Missing Link?Cellular and molecular gastroenterology and hepatology · 2016Article
- Building a Beneficial Microbiome from Birth.Advances in nutrition (Bethesda, Md.) · 2016Review
- Prebiotic administration normalizes lipopolysaccharide (LPS)-induced anxiety and cortical 5-HT2A receptor and IL1-β levels in male mice.Brain, behavior, and immunity · 2016Article
- Gut microbiome composition is associated with temperament during early childhood.Brain, behavior, and immunity · 2015Observational
- Genome of Bifidobacteria and Carbohydrate Metabolism.Korean journal for food science of animal resources · 2015Article
- The Neonatal Microbiome: Implications for Neonatal Intensive Care Unit Nurses.MCN. The American journal of maternal child nursingArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to systematically assess the bifidogenic effect of three commonly used prebiotic products using in vitro cultures of infant fecal samples. Fresh stool samples collected from six term infants, each exclusively fed human milk (n = 3) or infant formula (n = 3), at 28 days of age were used as inocula. The following prebiotic products were added at concentrations applicable to infant formula: Vivinal GOS 15 (containing 28.5% galacto-oligosaccharide [GOS]) at 7.2 g/liter, Beneo HP (99.5% long-chain inulin [IN]) at 0.8 g/liter, Beneo Synergy 1 (enriched oligofructose and inulin [OF-IN]) at 4 g/liter, and a combination of Vivinal GOS 15 (7.2 g/liter) and Beneo HP (0.8 g/liter) (GOS-IN). The growth of total bacteria, Bifidobacterium, Bacteroides, Bifidobacterium longum, and Escherichia coli was quantified using specific quantitative PCR (qPCR). Bifidobacterium was also enumerated on selective Beerens agar plates, with representative colonies identified by sequencing of their 16S rRNA genes. Volatile fatty acids (VFA) and pH in the cultures were also determined. Irrespective of the feeding methods, the GOS product, either alone or in combination with Beneo HP, resulted in substantially higher growth of total bifidobacteria, and much of this growth was attributed to growth of B. longum. Beneo Synergy 1 also increased the abundance of total bifidobacteria and B. longum. Corresponding to the increases in these two bacterial groups, acetic acid concentrations were higher, while there was a trend of lower E. coli levels and pH. The lower pH and higher acetic acid concentration might be directly responsible for the lower E. coli population. At the concentrations studied, the GOS product was more bifidogenic and potent in inhibiting E. coli than the other products tested. These results suggest that supplementation of infant formula with GOS may increase intestinal bifidobacteria and benefit infant health.
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