ArticleApplied and environmental microbiology2014
Time-Scaled Evolutionary Analysis of the Transmission and Antibiotic Resistance Dynamics of Staphylococcus aureus Clonal Complex 398.
Article in Applied and environmental microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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Who cites it
61 citing papers in PubMed.
- Mortality of CC398 Staphylococcus aureus bloodstream infections among hospitalised patients in a Swiss university hospital: a retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Prevalence and antimicrobial susceptibility ofOne health (Amsterdam, Netherlands) · 2026Article
- SAASI: Sampling Aware Ancestral State Inference.Nature communications · 2026Article
- Comparative Pan- and Phylo-Genomic Analysis of Ideonella and Thermobifida Strains: Dissemination of Biodegradation Potential and Genomic Divergence.Biochemical genetics · 2026Article
- Genetic dissection of sorghum [Frontiers in plant science · 2026Article
- Barriers to effective antimicrobial resistance management in Nigerian livestock: the role of veterinary practices and client expectations.BMC veterinary research · 2025Article
- Time-calibrated phylogenetic and chromosomal mobilome analyses of Staphylococcus aureus CC398 reveal geographical and host-related evolution.Nature communications · 2024Article
- Antimicrobial Resistance in Livestock: A Serious Threat to Public Health.Antibiotics (Basel, Switzerland) · 2024Review
- The effect of information provision on consumers' risk perceptions of, support for a ban, and behavioral intention towards the preventive use of antibiotics in food animals.BMC public health · 2024Article
- Commercial farmed swine harbour a variety of pathogenic bacteria and antimicrobial resistance genes.Journal of medical microbiology · 2024Article
- The intra-host evolutionary landscape and pathoadaptation of persistentMicrobial genomics · 2023Article
- Genome Analysis of Methicillin-Resistant and Methicillin-SusceptibleMicroorganisms · 2023Article
- Genomic epidemiology ofMicrobial genomics · 2023Observational
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- One Health WASH: an AMR-smart integrative approach to preventing and controlling infection in farming communities.BMJ global health · 2023Article
- Data integration in Bayesian phylogenetics.Annual review of statistics and its application · 2023Article
- Low-level colonization of methicillin-resistant Staphylococcus aureus in pigs is maintained by slowly evolving, closely related strains in Finnish pig farms.Acta veterinaria Scandinavica · 2022Article
- A scalable analytical approach from bacterial genomes to epidemiology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
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1 more citing papers are in PubMed but not listed here.
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Authors and funding
8 authors.
Funding
Abstract
Staphylococcus aureus clonal complex 398 (CC398) is associated with disease in humans and livestock, and its origins and transmission have generated considerable interest. We performed a time-scaled phylogenetic analysis of CC398, including sequenced isolates from the United Kingdom (Scotland), along with publicly available genomes. Using state-of-the-art methods for mapping traits onto phylogenies, we quantified transitions between host species to identify sink and source populations for CC398 and employed a novel approach to investigate the gain and loss of antibiotic resistance in CC398 over time. We identified distinct human- and livestock-associated CC398 clades and observed multiple transmissions of CC398 from livestock to humans and between countries, lending quantitative support to previous reports. Of note, we identified a subclade within the livestock-associated clade comprised of isolates from hospital environments and newborn babies, suggesting that livestock-associated CC398 is capable of onward transmission in hospitals. In addition, our analysis revealed significant differences in the dynamics of resistance to methicillin and tetracycline related to contrasting historical patterns of antibiotic usage between the livestock industry and human medicine. We also identified significant differences in patterns of gain and loss of different tetracycline resistance determinants, which we ascribe to epistatic interactions between the resistance genes and/or differences in the modes of inheritance of the resistance determinants.
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