Evidence map›Paper›PMID 25239842›Full record

ArticleAcademic radiology2014

CT texture analysis of renal masses: pilot study using random forest classification for prediction of pathology.

Siva P Raman, Yifei Chen, James L Schroeder, Peng Huang, Elliot K Fishman

Abstract read
In one paragraph

Article in Academic radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. SNMMI/EANM/ACNM Procedure Standard/Procedure Guideline on the Use of Molecular Imaging for Renal Mass Characterization.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2025
    Guideline
  2. Pooled it
  3. Article
  4. Article
  5. State of the art review of AI in renal imaging.Abdominal radiology (New York) · 2025
    Review
  6. Conventional chest computed tomography-based radiomics for predicting the risk of thoracolumbar osteoporotic vertebral fractures.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2025
    Article
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  13. Preoperative prediction of early recurrence in resectable pancreatic cancer integrating clinical, radiologic, and CT radiomics features.Cancer imaging : the official publication of the International Cancer Imaging Society · 2024
    Article
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8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Siva P RamanDepartment of Radiology, JHOC 3251, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287. Electronic address: sraman3@gmail.com.
Yifei ChenDepartment of Radiology, JHOC 3251, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287.
James L SchroederDepartment of Radiology, JHOC 3251, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287.
Peng HuangBiostatistics and Bioinformatics Division, Department of Oncology, Johns Hopkins University, Baltimore, Maryland.
Elliot K FishmanDepartment of Radiology, JHOC 3251, Johns Hopkins University, 601 N. Caroline Street, Baltimore, MD 21287.

Funding

Translational Research Central ServicesP30CA006973 · NCI · JOHNS HOPKINS UNIVERSITY · PI Rosalie Wollett · 1985 to 2026
$208.6M
Theranostic Imaging of Metastatic Prostate CancerP50CA103175 · NCI · JOHNS HOPKINS UNIVERSITY · PI BARKER, PETER B · 2003 to 2015
$17.9M
NCI NIH HHS P30 CA006973NCI NIH HHS P50 CA103175
6 · The paper itself

Abstract

RATIONALE AND

objectivesComputed tomography texture analysis (CTTA) allows quantification of heterogeneity within a region of interest. This study investigates the possibility of distinguishing between several common renal masses using CTTA-derived parameters by developing and validating a predictive model. MATERIALS AND

methodsCTTA software was used to analyze 20 clear cell renal cell carcinomas (RCCs), 20 papillary RCCs, 20 oncocytomas, and 20 renal cysts. Regions of interest were drawn around each mass on multiple slices in the arterial, venous, and delayed phases on renal mass protocol CT scans. Unfiltered images and spatial band-pass filtered images were analyzed to quantify heterogeneity. Random forest method was used to construct a predictive model to classify lesions using quantitative parameters. The model was externally validated on a separate set of 19 unknown cases.

resultsThe random forest model correctly categorized oncocytomas in 89% of cases (sensitivity = 89%, specificity = 99%), clear cell RCCs in 91% of cases (sensitivity = 91%, specificity = 97%), cysts in 100% of cases (sensitivity = 100%, specificity = 100%), and papillary RCCs in 100% of cases (sensitivity = 100%, specificity = 98%).

conclusionsCTTA, in conjunction with random forest modeling, demonstrates promise as a tool to characterize lesions. Various renal masses were accurately classified using quantitative information derived from routine scans.

Indexed as

Adenoma, OxyphilicAgedCarcinoma, Renal CellContrast MediaFemaleHumansIohexolKidney Diseases, CysticKidney NeoplasmsMaleMiddle AgedPredictive Value of TestsRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesSensitivity and SpecificitySoftwareContrast MediaiodixanolIohexolTriiodobenzoic Acidsclear cell renal cell carcinomamultidetector computed tomographyoncocytomapapillary renal cell carcinomaTexture analysis

Identifiers

PMID25239842
PMCPMC4352301

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.