ArticleAmerican journal of physiology. Heart and circulatory physiology2014
β-Adrenergic receptor blockade impairs coronary exercise hyperemia in young men but not older men.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Beta-1 vs. beta-2 adrenergic control of coronary blood flow during isometric handgrip exercise in humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Esmolol infusion versus propranolol infusion: effects on heart rate and blood pressure in healthy volunteers.Journal of applied physiology (Bethesda, Md. : 1985) · 2017Trial
- Ketone Bodies in the Regulation of Myocardial Perfusion in Cardiovascular Disease: Metabolic and Vasodilatory Effects.International journal of molecular sciences · 2025Review
- Effects of alpha-adrenergic receptor blockade on coronary circulation in postmenopausal women.European journal of applied physiology · 2023Article
- Sympathetic control of the coronary circulation during trigeminal nerve stimulation in humans.European journal of applied physiology · 2023Article
- Review
- Coronary vasomotion and exercise-induced adaptations in coronary artery disease patients: A systematic review and meta-analysis.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2020Review
- Article
- Endurance training attenuates the increase in peripheral chemoreflex sensitivity with intermittent hypoxia.American journal of physiology. Regulatory, integrative and comparative physiology · 2017Article
- Functional vascular contributions to cognitive impairment and dementia: mechanisms and consequences of cerebral autoregulatory dysfunction, endothelial impairment, and neurovascular uncoupling in aging.American journal of physiology. Heart and circulatory physiology · 2017Review
- Coronary Exercise Hyperemia Is Impaired in Patients with Peripheral Arterial Disease.Annals of vascular surgery · 2017Article
- Adrenergic signaling in heart failure and cardiovascular aging.Maturitas · 2016Review
- Effect of adrenergic agonists on coronary blood flow: a laboratory study in healthy volunteers.Physiological reports · 2016Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Patients with coronary artery disease have attenuated coronary vasodilator responses to physiological stress, which is partially attributed to a β-adrenergic receptor (β-AR)-mediated mechanisms. Whether β-ARs contribute to impaired coronary vasodilation seen with healthy aging is unknown. The purpose of this study was to investigate the role of β-ARs in coronary exercise hyperemia in healthy humans. Six young men (26 ± 1 yr) and seven older men (67 ± 4 yr) performed isometric handgrip exercise at 30% maximal voluntary contraction for 2 min after receiving intravenous propranolol, a β-AR antagonist, and no treatment. Isoproterenol, a β-AR agonist, was infused to confirm the β-AR blockade. Blood pressure and heart rate were monitored continuously, and coronary blood flow velocity (CBV, left anterior descending artery) was measured by transthoracic Doppler echocardiography. Older men had an attenuated ΔCBV to isometric exercise (3.8 ± 1.3 vs. 9.7 ± 2.1 cm/s, P = 0.02) compared with young men. Propranolol decreased the ΔCBV at peak handgrip exercise in young men (9.7 ± 2.1 vs. 2.7 ± 0.9 cm/s, P = 0.008). However, propranolol had no effect on ΔCBV in older men (3.8 ± 1.3 vs. 4.2 ± 1.9 cm/s, P = 0.9). Older men also had attenuated coronary hyperemia to low-dose isoproterenol. These data indicate that β-AR control of coronary blood flow is impaired in healthy older men.
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Registered trials
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