ArticleAmerican journal of physiology. Heart and circulatory physiology2014
Computational modeling of Takotsubo cardiomyopathy: effect of spatially varying β-adrenergic stimulation in the rat left ventricle.
Article in American journal of physiology. Heart and circulatory physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Developing cardiac biomechanical models beyond the clinic: modeling stressors of daily life.Biomechanics and modeling in mechanobiology · 2025Review
- Takotsubo Syndrome and Oxidative Stress: Physiopathological Linkage and Future Perspectives.Antioxidants (Basel, Switzerland) · 2025Review
- Role of miR-204 in segmental cardiac effects of phenylephrine and pressure overload.Biochemical and biophysical research communications · 2023Article
- Autonomic control of ventricular function in health and disease: current state of the art.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Review
- Molecular Mechanisms of Takotsubo Syndrome.International journal of molecular sciences · 2022Review
- Assessing the Role of High-Dose β-Agonists Use in Triggering Takotsubo Syndrome During Asthma Exacerbation.The Permanente journal · 2022Review
- Takotsubo Syndrome: Translational Implications and Pathomechanisms.International journal of molecular sciences · 2022Review
- Hyperthermia as a trigger for Takotsubo syndrome in a rat model.Frontiers in cardiovascular medicine · 2022Article
- Pathophysiology of Takotsubo Syndrome as A Bridge to Personalized Treatment.Journal of personalized medicine · 2021Review
- Combining tissue engineering and optical imaging approaches to explore interactions along the neuro-cardiac axis.Royal Society open science · 2020Review
- A short history of the development of mathematical models of cardiac mechanics.Journal of molecular and cellular cardiology · 2019Review
- Takotsubo Cardiomyopathy in a Patient with Undiscovered Sigmoid Colon Cancer.Case reports in cardiology · 2017Article
- Verification of cardiac mechanics software: benchmark problems and solutions for testing active and passive material behaviour.Proceedings. Mathematical, physical, and engineering sciences · 2015Article
- A Spatially Detailed Model of Isometric Contraction Based on Competitive Binding of Troponin I Explains Cooperative Interactions between Tropomyosin and Crossbridges.PLoS computational biology · 2015Article
- Epidemiology and pathophysiology of Takotsubo syndrome.Nature reviews. Cardiology · 2015Review
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
Abstract
In Takotsubo cardiomyopathy, the left ventricle shows apical ballooning combined with basal hypercontractility. Both clinical observations in humans and recent experimental work on isolated rat ventricular myocytes suggest the dominant mechanisms of this syndrome are related to acute catecholamine overload. However, relating observed differences in single cells to the capacity of such alterations to result in the extreme changes in ventricular shape seen in Takotsubo syndrome is difficult. By using a computational model of the rat left ventricle, we investigate which mechanisms can give rise to the typical shape of the ventricle observed in this syndrome. Three potential dominant mechanisms related to effects of β-adrenergic stimulation were considered: apical-basal variation of calcium transients due to differences in L-type and sarco(endo)plasmic reticulum Ca(2+)-ATPase activation, apical-basal variation of calcium sensitivity due to differences in troponin I phosphorylation, and apical-basal variation in maximal active tension due to, e.g., the negative inotropic effects of p38 MAPK. Furthermore, we investigated the interaction of these spatial variations in the presence of a failing Frank-Starling mechanism. We conclude that a large portion of the apex needs to be affected by severe changes in calcium regulation or contractile function to result in apical ballooning, and smooth linear variation from apex to base is unlikely to result in the typical ventricular shape observed in this syndrome. A failing Frank-Starling mechanism significantly increases apical ballooning at end systole and may be an important additional factor underpinning Takotsubo syndrome.
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