Evidence map›Paper›PMID 25239789›Full record

ArticleClinical radiology2014

Intra-individual comparison of magnesium citrate and sodium phosphate for bowel preparation at CT colonography: automated volumetric analysis of residual fluid for quality assessment.

P Bannas, J Bakke, A Munoz del Rio, P J Pickhardt

Abstract readComparative Study
In one paragraph

Article in Clinical radiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 2 countries.

P BannasDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA; Department of Radiology, University Hospital Hamburg-Eppendorf, Hamburg, Germany. Electronic address: pbannas@uwhealth.org.
J BakkeDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
A Munoz del RioDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
P J PickhardtDepartment of Radiology, University of Wisconsin School of Medicine & Public Health, Madison, WI, USA.
University of Wisconsin–Madison · US

Funding

Virtual Colonoscopy and Colorectal Cancer ScreeningR01CA144835 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI PICKHARDT, PERRY, SMITH, MAUREEN A · 2010 to 2013
$2.1M
Ultra-Low Radiation Dose Body CT ImagingR01CA169331 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI CHEN, GUANG-HONG, PICKHARDT, PERRY · 2012 to 2016
$1.4M
NCI NIH HHS 1R01CA144835-01NCI NIH HHS 1R01CA169331-01NCI NIH HHS R01 CA144835NCI NIH HHS R01 CA169331
6 · The paper itself

Abstract

aimTo perform an objective, intra-individual comparison of residual colonic fluid volume and attenuation associated with the current front-line laxative magnesium citrate (MgC) versus the former front-line laxative sodium phosphate (NaP) at CT colonography (CTC). MATERIALS AND

methodsThis retrospective Health Insurance and Portability and Accountability Act-compliant study had institutional review board approval; informed consent was waived. The study cohort included 250 asymptomatic adults (mean age at index 56.1 years; 124 male/126 female) who underwent CTC screening twice over a 5 year interval. Colon catharsis at initial and follow-up screening employed single-dose NaP and double-dose MgC, respectively, allowing for intra-patient comparison. Automated volumetric analysis of residual colonic fluid volume and attenuation was performed on all 500 CTC studies. Colonic fluid volume <200 ml and mean attenuation between 300-900 HU were considered optimal. Paired t-test and McNemar's test were used to compare differences.

resultsResidual fluid volumes <200 ml were recorded in 192 examinations (76.8%) following MgC and in 204 examinations (81.6%) following NaP (p = 0.23). The mean total residual fluid volume was 155 ± 114 ml for MgC and 143 ± 100 ml for NaP (p = 0.01). The attenuation range of 300-900 HU was significantly more frequent for MgC (n = 220, 88%) than for NaP (n = 127, 50.8%; p < 0.001). Mean fluid attenuation was significantly lower for MgC (700 ± 165 HU) than for NaP (878 ± 155 HU; p < 0.001). Concomitant presence of both optimal fluid volume and attenuation was significantly more frequent for MgC 65.2% than for NaP (38%; p < 0.001).

conclusionsObjective intra-individual comparison using automated volumetric analysis suggests that the replacement of NaP by MgC as the front-line laxative for CTC has not compromised overall examination quality.

Indexed as

Colonography, Computed TomographicAgedCatharticsCitric AcidFemaleHumansMaleMiddle AgedOrganometallic CompoundsPhosphatesQuality Assurance, Health CareRadiographic Image Interpretation, Computer-AssistedRetrospective StudiesSoftwareCatharticsCitric Acidmagnesium citrateOrganometallic CompoundsPhosphatessodium phosphate

Identifiers

PMID25239789
PMCPMC4201391
OpenAlexW2130953575

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.