ArticleToxicological sciences : an official journal of the Society of Toxicology2014
Inhaled diesel emissions generated with cerium oxide nanoparticle fuel additive induce adverse pulmonary and systemic effects.
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In one paragraph
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
0numbers the graph read from it
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16citing papers in PubMed
5.3field-weighted citation impact, top 5% of its field
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 63 citations in OpenAlex.
- Review
- Toxicity assessment of CeO₂ and CuO nanoparticles at the air-liquid interface using bioinspired condensational particle growth.Hygiene and environmental health advances · 2023Article
- Combined Toxicity of Metal Nanoparticles: Comparison of Individual and Mixture Particles Effect.Advances in experimental medicine and biology · 2021Article
- Cerium Oxide Nanoparticles and Their Efficient Antibacterial ApplicationNanomaterials (Basel, Switzerland) · 2020Article
- Vehicular Particulate Matter (PM) Characteristics Impact Vascular Outcomes Following Inhalation.Cardiovascular toxicology · 2020Article
- Cerium Oxide Nanoparticles Absorption through Intact and Damaged Human Skin.Molecules (Basel, Switzerland) · 2019Article
- Aortic Oxidative Stress, Inflammation and DNA Damage Following Pulmonary Exposure to Cerium Oxide Nanoparticles in a Rat Model of Vascular Injury.Biomolecules · 2019Article
- Pulmonary toxicity of inhaled nano-sized cerium oxide aerosols in Sprague-Dawley rats.Nanotoxicology · 2019Article
- Douglas-Fir ( Pseudotsuga menziesii (Mirb.) Franco) Transcriptome Profile Changes Induced by Diesel Emissions Generated with CeOEnvironmental science & technology · 2018Article
- Effects of Simulated Smog Atmospheres in Rodent Models of Metabolic and Immunologic Dysfunction.Environmental science & technology · 2018Article
- Comparative toxicity of seven rare earth elements in sea urchin early life stages.Environmental science and pollution research international · 2017Article
- Cerium oxide nanoparticles inhibit differentiation of neural stem cells.Scientific reports · 2017Article
- Cerium Oxide Nanoparticles in Lung Acutely Induce Oxidative Stress, Inflammation, and DNA Damage in Various Organs of Mice.Oxidative medicine and cellular longevity · 2017Article
- The acute pulmonary and thrombotic effects of cerium oxide nanoparticles after intratracheal instillation in mice.International journal of nanomedicine · 2017Article
- In vivo biodistribution and physiologically based pharmacokinetic modeling of inhaled fresh and aged cerium oxide nanoparticles in rats.Particle and fibre toxicology · 2016Article
- Effects of amorphous silica coating on cerium oxide nanoparticles induced pulmonary responses.Toxicology and applied pharmacology · 2015Article
Corrections and comments
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Authors and funding
21 authors at 4 institutions in 1 country.
Samantha J Snow*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703 *Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, Na
John McGee*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Desinia B Miller*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Virginia Bass*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Mette C Schladweiler*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Ronald F Thomas*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Todd Krantz*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Charly King*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Allen D Ledbetter*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Judy Richards*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Jason P Weinstein*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Teri Conner*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Robert Willis*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
William P Linak*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
David Nash*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703 *Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, Na
Charles E Wood*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Susan A Elmore*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
James P Morrison*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Crystal L Johnson*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Matthew Ian Gilmour*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Urmila P Kodavanti*Curriculum in Toxicology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Public Health Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Department of Environmental Science and Engineering, Gillings School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, Environmental Characterization and Apportionment Branch, NERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Air Pollution Prevention and Control Division, NRMRL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, Arcadis US Inc., Durham, North Carolina, 27713, Integrated Systems Toxicology Division, NHEERL, US Environmental Protection Agency, Research Triangle Park, North Carolina, 27711, National Toxicology Program Division, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina, 27711 and Pathology Associates Inc., Charles River Laboratories, Durham, North Carolina, 27703.
Environmental Protection Agency · USResearch Triangle Park Foundation · USNational Institutes of Health · USUniversity of North Carolina at Chapel Hill · US
Funding
TOXICOLOGYT32ES007126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ILONA JASPERS, Bernard E. Weissman · 1985 to 2026
$13.0MNIEHS NIH HHS T32 ES007126
Abstract
Diesel exhaust (DE) exposure induces adverse cardiopulmonary effects. Cerium oxide nanoparticles added to diesel fuel (DECe) increases fuel burning efficiency but leads to altered emission characteristics and potentially altered health effects. Here, we evaluated whether DECe results in greater adverse pulmonary effects compared with DE. Male Sprague Dawley rats were exposed to filtered air, DE, or DECe for 5 h/day for 2 days. N-acetyl glucosaminidase activity was increased in bronchial alveolar lavage fluid (BALF) of rats exposed to DECe but not DE. There were also marginal but insignificant increases in several other lung injury biomarkers in both exposure groups (DECe > DE for all). To further characterize DECe toxicity, rats in a second study were exposed to filtered air or DECe for 5 h/day for 2 days or 4 weeks. Tissue analysis indicated a concentration- and time-dependent accumulation of lung and liver cerium followed by a delayed clearance. The gas-phase and high concentration of DECe increased lung inflammation at the 2-day time point, indicating that gas-phase components, in addition to particles, contribute to pulmonary toxicity. This effect was reduced at 4 weeks except for a sustained increase in BALF γ-glutamyl transferase activity. Histopathology and transmission electron microscopy revealed increased alveolar septa thickness due to edema and increased numbers of pigmented macrophages after DECe exposure. Collectively, these findings indicate that DECe induces more adverse pulmonary effects on a mass basis than DE. In addition, lung accumulation of cerium, systemic translocation to the liver, and delayed clearance are added concerns to existing health effects of DECe.
Indexed as
AcetylglucosaminidaseAnimalsAortaBronchoalveolar Lavage FluidCeriumDose-Response Relationship, DrugGasolineLiverLungLung InjuryMaleMicroscopy, Electron, TransmissionNanoparticlesParticle SizeRats, Sprague-DawleyTime FactorsAcetylglucosaminidaseceric oxideCeriumGasolineVehicle Emissionscardiopulmonarycerium oxidediesel exhaustnanoparticle
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