Evidence map›Paper›PMID 25238890›Full record

ReviewInternational urology and nephrology2014

Pathophysiology and animal modeling of underactive bladder.

Pradeep Tyagi, Phillip P Smith, George A Kuchel, William C de Groat, Lori A Birder, Christopher J Chermansky, Rosalyn M Adam, Vincent Tse, Michael B Chancellor, Naoki Yoshimura

Abstract readReview
In one paragraph

Review in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed.

  1. Article
  2. The underappreciated underactive bladder.Translational andrology and urology · 2025
    Review
  3. Article
  4. Article
  5. Association of detrusor underactivity with aging and metabolic syndrome: suggestions from animal models.Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Micturition defects and altered bladder function in theAmerican journal of clinical and experimental urology · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. AlphaBMC urology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pradeep TyagiDepartment of Urology, University of Pittsburgh, Pittsburgh, PA, USA.
Phillip P Smith
George A Kuchel
William C de Groat
Lori A Birder
Christopher J Chermansky
Rosalyn M Adam
Vincent Tse
Michael B Chancellor
Naoki Yoshimura

Funding

Bladder Nociception: function/central projection of Sympathetic Afferent PathwayR01DK091253 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DEGROAT, WILLIAM C · 2011 to 2015
$1.7M
First Congress of Urologic Research and Education on Aging UnderActive BladderR13AG047010 · NIA · WILLIAM BEAUMONT HOSPITAL RESEARCH INST · PI CHANCELLOR, MICHAEL B · 2014 to 2019
$275k
NIA NIH HHS R13 AG047010NIDDK NIH HHS R01 DK091253
6 · The paper itself

Abstract

While the symptomology of underactive bladder (UAB) may imply a primary dysfunction of the detrusor muscle, insights into pathophysiology indicate that both myogenic and neurogenic mechanisms need to be considered. Due to lack of proper animal models, the current understanding of the UAB pathophysiology is limited, and much of what is known about the clinical etiology of the condition has been derived from epidemiological data. We hereby review current state of the art in the understanding of the pathophysiology of and animal models used to study the UAB.

Indexed as

Disease Models, AnimalAgingAnimalsAnimals, Genetically ModifiedMiceMuscle, SmoothParkinson DiseasePeripheral Nerve InjuriesReceptors, ProstaglandinReceptors, PurinergicSpinal Cord InjuriesSpinal StenosisUrinary BladderUrinary Bladder DiseasesUrinary Bladder Neck ObstructionReceptors, ProstaglandinReceptors, Purinergic

Identifiers

PMID25238890
PMCPMC4469340

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.