ArticleBMC research notes2014
Dietary xylo-oligosaccharide stimulates intestinal bifidobacteria and lactobacilli but has limited effect on intestinal integrity in rats.
Article in BMC research notes, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
43 citing papers in PubMed, 83 citations in OpenAlex.
- Dietary halloysite supplementation in Orvia ducks: effects on production performance, meat quality, blood biochemistry, muscle histological and molecular traits.Poultry science · 2026Article
- Unveiling functional heterogeneity in pasteurizedFrontiers in nutrition · 2026Article
- A Dietary Supplement Containing Nucleotides, Oligosaccharides, Vitamin E and β-Carotene Promotes Immune Response and Gut Microbiota Changes in Kittens.Animals : an open access journal from MDPI · 2025Article
- Oral amoxicillin treatment disrupts the gut microbiome and metabolome without interfering with luminal redox potential in the intestine of Wistar Han rats.FEMS microbiology ecology · 2025Article
- Thiamine-Reduced Fatigue in Quiescent Inflammatory Bowel Disease Is Linked toGastro hep advances · 2025Article
- In vitro and in vivo investigation of the biological action of xylooligosaccharides derived from industrial waste.Food science & nutrition · 2024Article
- The effect of coffee husks used as pellet bedding material on the intestinal barrier, immune-related gene expression and microbiota composition in the broiler chicken caecum.Journal of veterinary research · 2024Article
- A syrup containing L-arabinose and D-xylose appears superior to PEG-4000 as a bowel cleansing agent.AMB Express · 2024Article
- Recent Advances in Biomedical Applications of Mannans and Xylans.Current drug targets · 2024Review
- Identification of inulin-responsive bacteria in the gut microbiota via multi-modal activity-based sorting.Nature communications · 2023Article
- Dietary Supplementation with Nucleotides, Short-Chain Fructooligosaccharides, Xylooligosaccharides, Beta-Carotene and Vitamin E Influences Immune Function in Kittens.Animals : an open access journal from MDPI · 2023Article
- A prebiotic diet modulates the oral microbiome composition and results in the attenuation of oropharyngeal candidiasis in mice.Microbiology spectrum · 2023Article
- Canagliflozin protects the cardiovascular system through effects on the gut environment in non-diabetic nephrectomized rats.Clinical and experimental nephrology · 2023Article
- Effect of Arabinoxylan and Xylo-Oligosaccharide on Growth Performance and Intestinal Barrier Function in Weaned Piglets.Animals : an open access journal from MDPI · 2023Article
- Alterations in the Fecal Microbiota Composition in Pediatric Acute Diarrhea: A Cross-Sectional and Comparative Study of Viral and Bacterial Enteritis.Infection and drug resistance · 2023Article
- Review
- Xylan Prebiotics and the Gut Microbiome Promote Health and Wellbeing: Potential Novel Roles for Pentosan Polysulfate.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Amoxicillin does not affect the development of cow's milk allergy in a Brown Norway rat model.Scandinavian journal of immunology · 2022Article
- Article
- Assessment of the bifidogenic and antibacterial activities of xylooligosaccharide.Frontiers in nutrition · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConsumption of prebiotics may modulate gut microbiota, subsequently affecting the bacterial composition, metabolite profile, and human health. Previous studies indicate that also changes in intestinal integrity may occur. In order to explore this further we have investigated the effect of the putative prebiotic xylo-oligosaccharides (XOS) on the gut microbiota and intestinal integrity in male Wistar rats. As changes in intestinal integrity may be related to the expected bifidogenic effect of XOS, we additionally addressed effects of supplementation with a commensal Bifidobacterium pseudolongum (BIF) isolated from the same breed of laboratory rats.
resultsChanges in faecal and caecal bacterial composition determined by 16S rRNA gene sequencing and quantitative PCR for selected bacterial groups revealed that the overall bacterial composition did not differ markedly between the control (CON), XOS, and BIF groups, when correcting for multiple comparisons. However as hypothesised, the relative abundance of Bifidobacterium spp. was increased in XOS-fed rats as compared to CON in faecal samples after the intervention. Also Lactobacillus spp. was increased in both the XOS and BIF groups in caecum content compared to CON. Intestinal permeability determined in vivo by FITC-dextran permeability and in vitro using extracted caecum water in trans-epithelial resistance (TER) assay showed no effect on intestinal integrity in either the XOS or the BIF groups. However, the expression of occludin, which is part of the tight junction complex, was increased in the XOS group compared to the CON group.
conclusionsSupplementation with XOS or a commensal Bifidobacterium pseudolongum had very limited effects on intestinal integrity in rats as only significant change in expression of a single tight junction protein gene was found for the XOS group.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.