ArticleCurrent treatment options in neurology2014
Restless legs syndrome: pathophysiology and treatment.
Article in Current treatment options in neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Pooled it
- Comparing Gabapentin with Clonazepam for Residual Sleeping Problems following Antidepressant Therapy in Patients with Major Depressive Disorder: A Randomized Clinical Trial.Clinical drug investigation · 2015Trial
- Sleep and Athletic Performance: A Multidimensional Review of Physiological and Molecular Mechanisms.Journal of clinical medicine · 2025Review
- Restless Eyes at Night: A Novel Variant of Restless Legs Syndrome.European journal of case reports in internal medicine · 2025Article
- Evaluation of the relationship between idiopathic restless legs syndrome and serum hepcidin levels.Brain and behavior · 2023Article
- Review
- Restless legs syndrome.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2017Article
- Review
- Restless legs syndrome-current therapies and management of augmentation.Nature reviews. Neurology · 2015Review
- Review
- Sleep disorders in multiple sclerosis. Review.Current neurology and neuroscience reports · 2015Review
- Sleep disorders in patients with multiple sclerosis.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2015Article
- Exercise as a favorable non-pharmacologic treatment to Sleep-Related Movement Disorders: a review.Sleep science (Sao Paulo, Brazil)Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
opinion statementRestless legs syndrome (RLS) is a complicated sensory-motor syndrome. The pathology is increasingly understood, but a clear physiologic understanding still remains elusive. The most robust findings remain reduced central nervous system (CNS) iron and some perturbation in dopaminergic systems. Other neurotransmitter systems are also like involved, and the phenotype may result from distinct pathophysiologic processes. Treatment of RLS is often very successful, and treatment goals should be high. Dopamine agonists may most robustly improve pure urge to move and certainly periodic limb movements. They do not directly improve sleep, and long-term use is limited by augmentation. Alpha-2-delta ligand drugs such as gabapentin enacarbil and pregabalin improve RLS, presumably in a less specific manner. These drugs increase slow wave sleep and improve pain, but have less impact on leg movements. Mu specific opioids also robustly improve RLS and are probably underutilized in severe cases. Intravenous iron inconsistently but sometimes considerably improves RLS and can be considered in refractory cases.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.