Evidence map›Paper›PMID 25238560›Full record

ReviewJournal of physics. Condensed matter : an Institute of Physics journal2014

Close encounters with DNA.

C Maffeo, J Yoo, J Comer, D B Wells, B Luan, A Aksimentiev

Abstract readReview
In one paragraph

Review in Journal of physics. Condensed matter : an Institute of Physics journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Toothbrushes as a Source of DNA for Gender and Human Identification-A Systematic Review.International journal of environmental research and public health · 2021
    Pooled it
  2. Article
  3. SurFlex microscopy: Measuring flexibility of surface-tethered biomolecules.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Article
  6. Stacking Interactions and Flexibility of Human Telomeric Multimers.Journal of the American Chemical Society · 2023
    Article
  7. Article
  8. Article
  9. Dynamics of KThe European physical journal. E, Soft matter · 2020
    Article
  10. Article
  11. Review
  12. Article
  13. Charge Neutralization Drives the Shape Reconfiguration of DNA Nanotubes.Angewandte Chemie (International ed. in English) · 2018
    Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

C MaffeoDepartment of Physics, University of Illinois, Urbana, IL, USA.
J Yoo
J Comer
D B Wells
B Luan
A Aksimentiev

Funding

Nanopore sequencing of DNA with MspAR01HG005115 · NHGRI · UNIVERSITY OF WASHINGTON · PI GUNDLACH, JENS, LASZLO, ANDREW · 2009 to 2024
$14.0M
Plasmonic nanopores for trapping, controlled motion and sequencing of DNAR01HG007406 · NHGRI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI AKSIMENTIEV, ALEKSEI · 2013 to 2016
$2.4M
NHGRI NIH HHS R01 HG005115NHGRI NIH HHS R01-HG005115NHGRI NIH HHS R01 HG007406NHGRI NIH HHS R01-HG007406
6 · The paper itself

Abstract

Over the past ten years, the all-atom molecular dynamics method has grown in the scale of both systems and processes amenable to it and in its ability to make quantitative predictions about the behavior of experimental systems. The field of computational DNA research is no exception, witnessing a dramatic increase in the size of systems simulated with atomic resolution, the duration of individual simulations and the realism of the simulation outcomes. In this topical review, we describe the hallmark physical properties of DNA from the perspective of all-atom simulations. We demonstrate the amazing ability of such simulations to reveal the microscopic physical origins of experimentally observed phenomena. We also discuss the frustrating limitations associated with imperfections of present atomic force fields and inadequate sampling. The review is focused on the following four physical properties of DNA: effective electric charge, response to an external mechanical force, interaction with other DNA molecules and behavior in an external electric field.

Indexed as

Computer SimulationDNAModels, MolecularMolecular Dynamics SimulationStatic ElectricityDNA

Identifiers

PMID25238560
PMCPMC4207370

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.