ArticlePloS one2014
SPI-23 of S. Derby: role in adherence and invasion of porcine tissues.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed.
- Infection biology ofEcoSal Plus · 2024Review
- The Salmonella enterica EnvE is an Outer Membrane Lipoprotein and Its Gene Expression Leads to Transcriptional Repression of the Virulence Gene msgA.Journal of microbiology (Seoul, Korea) · 2024Article
- Meningitis and Bacteremia by Unusual Serotype ofInterdisciplinary perspectives on infectious diseases · 2024Article
- Intracranial infection and sepsis in infants caused byWorld journal of clinical cases · 2023Article
- Incidence and Genomic Background of Antibiotic Resistance in Food-Borne and Clinical Isolates ofAntibiotics (Basel, Switzerland) · 2023Article
- Microbial Genetics and Clonal Dissemination of Salmonella enterica Serotype Javiana Isolated from Human Populations in Arkansas, USAPathogens (Basel, Switzerland) · 2022Article
- Prevalence, Characterization, and Pathogenicity ofAnimals : an open access journal from MDPI · 2021Article
- Prevalence of IncFIB Plasmids Found amongPathogens (Basel, Switzerland) · 2021Article
- Long-Read Sequencing Reveals Evolution and Acquisition of Antimicrobial Resistance and Virulence Genes inFrontiers in microbiology · 2021Article
- Mutation of hilD in a Salmonella Derby lineage linked to swine adaptation and reduced risk to human health.Scientific reports · 2020Article
- Comparative Genomic Analysis of 450 Strains ofGenes · 2020Article
- Municipal Wastewater Surveillance Revealed a High Community Disease Burden of a Rarely Reported and Possibly SubclinicalApplied and environmental microbiology · 2020Article
- Article
- Oral and intestinal bacterial exotoxins: Potential linked to carcinogenesis.Progress in molecular biology and translational science · 2020Review
- Genetic Diversity ofPathogens (Basel, Switzerland) · 2019Article
- Non-typhoidalPathogens (Basel, Switzerland) · 2019Review
- Embracing Diversity: Differences in Virulence Mechanisms, Disease Severity, and Host Adaptations Contribute to the Success of NontyphoidalFrontiers in microbiology · 2019Review
- Complete Genome Sequence of Salmonella enterica subsp. enterica Serotype Derby, Associated with the Pork Sector in France.Microbiology resource announcements · 2018Article
- Polyphyletic Nature ofFrontiers in microbiology · 2018Article
- Population structure and associated phenotypes of Salmonella enterica serovars Derby and Mbandaka overlap with host range.BMC microbiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
Abstract
Salmonella enterica serovars Derby and Mbandaka are isolated from different groups of livestock species in the UK. S. Derby is predominantly isolated from pigs and turkeys and S. Mbandaka is predominantly isolated from cattle and chickens. Alignment of the genome sequences of two isolates of each serovar led to the discovery of a new putative Salmonella pathogenicity island, SPI-23, in the chromosome sequence of S. Derby isolates. SPI-23 is 37 kb in length and contains 42 ORFs, ten of which are putative type III effector proteins. In this study we use porcine jejunum derived cell line IPEC-J2 and in vitro organ culture of porcine jejunum and colon, to characterise the association and invasion rates of S. Derby and S. Mbandaka, and tissue tropism of S. Derby respectively. We show that S. Derby invades and associates to an IPEC-J2 monolayer in significantly greater numbers than S. Mbandaka, and that S. Derby preferentially attaches to porcine jejunum over colon explants. We also show that nine genes across SPI-23 are up-regulated to a greater degree in the jejunum compared to the colon explants. Furthermore, we constructed a mutant of the highly up-regulated, pilV-like gene, potR, and find that it produces an excess of surface pili compared to the parent strain which form a strong agglutinating phenotype interfering with association and invasion of IPEC-J2 monolayers. We suggest that potR may play a role in tissue tropism.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.