ArticleRejuvenation research2014
Curcumin's neuroprotective efficacy in Drosophila model of idiopathic Parkinson's disease is phase specific: implication of its therapeutic effectiveness.
Article in Rejuvenation research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 47 citations in OpenAlex.
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- Potential role of different animal models for the evaluation of bioactive compounds.Annals of medicine and surgery (2012) · 2025Review
- A Simple Immunofluorescence Method to Characterize Neurodegeneration and Tyrosine Hydroxylase Reduction in Whole Brain of aBio-protocol · 2024Article
- Fluorescence microscopy-based sensitive method to quantify dopaminergic neurodegeneration in aFrontiers in neuroscience · 2023Article
- Sexual dysfunction precedes motor defects, dopaminergic neuronal degeneration, and impaired dopamine metabolism: Insights fromFrontiers in neuroscience · 2023Article
- The dual role of heme oxygenase in regulating apoptosis in the nervous system ofFrontiers in physiology · 2023Article
- Changes in heme oxygenase level during development affect the adult life ofFrontiers in cellular neuroscience · 2023Article
- Natural Antioxidant Compounds as Potential Pharmaceutical Tools against Neurodegenerative Diseases.ACS omega · 2022Review
- Adult health and transition stage-specific rotenone-mediatedFrontiers in molecular neuroscience · 2022Article
- Management of altered metabolic activity inExperimental biology and medicine (Maywood, N.J.) · 2022Article
- Regulation of Heme Oxygenase and Its Cross-Talks with Apoptosis and Autophagy under Different Conditions inAntioxidants (Basel, Switzerland) · 2021Article
- Curcumin attenuates copper-induced oxidative stress and neurotoxicity inToxicology reports · 2020Article
- Protective Effects of Antioxidants in Huntington's Disease: an Extensive Review.Neurotoxicity research · 2019Review
- Curcumin-supplemented diets improve antioxidant enzymes and alter acetylcholinesterase genes expression level in Drosophila melanogaster model.Metabolic brain disease · 2018Article
- Exposure ofOxidative medicine and cellular longevity · 2018Article
- Recent developments in solid lipid nanoparticle and surface-modified solid lipid nanoparticle delivery systems for oral delivery of phyto-bioactive compounds in various chronic diseases.International journal of nanomedicine · 2018Review
- Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson's disease models.International journal of nanomedicine · 2015Review
- Spectroscopic and E-tongue evaluation of medicinal plants: A taste of how rasa can be studied.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Selective degeneration of dopaminergic neurons in the substantia nigra underlies the basic motor impairments of Parkinson's disease (PD). Curcumin has been used for centuries in traditional medicines in India. Our aim is to understand the efficacy of genotropic drug curcumin as a neuroprotective agent in PD. Analysis of different developmental stages in model organisms revealed that they are characterized by different patterns of gene expression which is similar to that of developmental stages of human. Genotropic drugs would be effective only during those life cycle stages for which their target molecules are available. Hence there exists a possibility that targets of genotropic compounds such as curcumin may not be present in all life stages. However, no reports are available in PD models illustrating the efficacy of curcumin in later phases of adult life. This is important because this is the period during which late-onset disorders such as idiopathic PD set in. To understand this paradigm, we tested the protective efficacy of curcumin in different growth stages (early, late health stage, and transition phase) in adult Drosophila flies. Results showed that it can rescue the motor defects during early stages of life but is ineffective at later phases. This observation was substantiated with the finding that curcumin treatment could replenish depleted brain dopamine levels in the PD model only during early stages of life cycle, clearly suggesting its limitation as a therapeutic agent in late-onset neurodegenerative disorders such as PD.
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