ArticlePloS one2014
Proteome analysis of human sebaceous follicle infundibula extracted from healthy and acne-affected skin.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 62 citations in OpenAlex.
- The Bacterial Landscape of Facial Skin: From Homeostasis to Skin Conditions.Dermatology and therapy · 2026Review
- Unraveling the Enigmatic Behavior ofInternational journal of microbiology · 2026Article
- Transcriptomic Analyses Predict Enhanced Metabolic Activity and Therapeutic Potential of mTOR Inhibitors in Acne-Prone Skin.JID innovations : skin science from molecules to population health · 2024Article
- A review of skin immune processes in acne.Frontiers in immunology · 2023Review
- Skin dysbiosis and Cutibacterium acnes biofilm in inflammatory acne lesions of adolescents.Scientific reports · 2022Article
- Acne, Microbiome, and Probiotics: The Gut-Skin Axis.Microorganisms · 2022Review
- Characterization of aInternational journal of molecular sciences · 2022Article
- Comparative Proteomic Analysis of Membrane Vesicles from ClinicalClinical, cosmetic and investigational dermatology · 2022Article
- Solution Structure of theFrontiers in cellular and infection microbiology · 2022Article
- Association of TNF-α polymorphisms (-857, -863 and -1031), TNF-α serum level and lipid profile with acne vulgaris.Saudi journal of biological sciences · 2021Article
- Review
- A Janus-Faced Bacterium: Host-Beneficial and -Detrimental Roles ofFrontiers in microbiology · 2021Review
- Review
- Mutant Lef1 controls Gata6 in sebaceous gland development and cancer.The EMBO journal · 2019Article
- Host-microbiome interactions and recent progress into understanding the biology of acne vulgaris.Microbiome · 2018Review
- Skin microbiota-host interactions.Nature · 2018Review
- Article
- Article
- Characterization of a Propionibacterium acnes Surface Protein as a Fibrinogen-Binding Protein.Scientific reports · 2017Article
- Shaping of cutaneous function by encounters with commensals.The Journal of physiology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acne vulgaris is a very common disease of the pilosebaceous unit of the human skin. The pathological processes of acne are not fully understood. To gain further insight sebaceous follicular casts were extracted from 18 healthy and 20 acne-affected individuals by cyanoacrylate-gel biopsies and further processed for mass spectrometry analysis, aiming at a proteomic analysis of the sebaceous follicular casts. Human as well as bacterial proteins were identified. Human proteins enriched in acne and normal samples were detected, respectively. Normal follicular casts are enriched in proteins such as prohibitins and peroxiredoxins which are involved in the protection from various stresses, including reactive oxygen species. By contrast, follicular casts extracted from acne-affected skin contained proteins involved in inflammation, wound healing and tissue remodeling. Among the most distinguishing proteins were myeloperoxidase, lactotransferrin, neutrophil elastase inhibitor and surprisingly, vimentin. The most significant biological process among all acne-enriched proteins was 'response to a bacterium'. Identified bacterial proteins were exclusively from Propionibacterium acnes. The most abundant P. acnes proteins were surface-exposed dermatan sulphate adhesins, CAMP factors, and a so far uncharacterized lipase in follicular casts extracted from normal as well as acne-affected skin. This is a first proteomic study that identified human proteins together with proteins of the skin microbiota in sebaceous follicular casts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.