ArticlePloS one2014
Associations between changes in city and address specific temperature and QT interval--the VA Normative Aging Study.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 20 citations in OpenAlex.
- Climate change and its environmental and health effects from 2015 to 2022: A scoping review.Heliyon · 2025Review
- Health Risks of Temperature Variability on Hospital Admissions in Cape Town, 2011-2016.International journal of environmental research and public health · 2023Article
- Psychological Stress and Epigenetic Aging in Older Men: The VA Normative Aging Study.Translational medicine of aging · 2023Article
- Combined Effects of Age and Comorbidities on Electrocardiographic Parameters in a Large Non-Selected Population.Journal of clinical medicine · 2022Article
- Associations between acute and long-term exposure to PM2.5 components and temperature with QT interval length in the VA Normative Aging Study.European journal of preventive cardiology · 2021Article
- Associations of Plasma Folate and Vitamin B6 With Blood DNA Methylation Age: An Analysis of One-Carbon Metabolites in the VA Normative Aging Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Associations between PMEnvironmental research · 2021Article
- Individual species and cumulative mixture relationships of 24-hour urine metal concentrations with DNA methylation age variables in older men.Environmental research · 2020Article
- Association of outdoor temperature with lung function in a temperate climate.The European respiratory journal · 2019Article
- Short-term effects of air temperature and mitochondrial DNA lesions within an older population.Environment international · 2017Article
- Effect of daily temperature range on respiratory health in Argentina and its modification by impaired socio-economic conditions and PM10 exposures.Environmental pollution (Barking, Essex : 1987) · 2015Article
- Disentangling interactions between atmospheric pollution and weather.Journal of epidemiology and community health · 2015Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundThe underlying mechanisms of the association between ambient temperature and cardiovascular morbidity and mortality are not well understood, particularly for daily temperature variability. We evaluated if daily mean temperature and standard deviation of temperature was associated with heart rate-corrected QT interval (QTc) duration, a marker of ventricular repolarization in a prospective cohort of older men.
methodsThis longitudinal analysis included 487 older men participating in the VA Normative Aging Study with up to three visits between 2000-2008 (n = 743). We analyzed associations between QTc and moving averages (1-7, 14, 21, and 28 days) of the 24-hour mean and standard deviation of temperature as measured from a local weather monitor, and the 24-hour mean temperature estimated from a spatiotemporal prediction model, in time-varying linear mixed-effect regression. Effect modification by season, diabetes, coronary heart disease, obesity, and age was also evaluated.
resultsHigher mean temperature as measured from the local monitor, and estimated from the prediction model, was associated with longer QTc at moving averages of 21 and 28 days. Increased 24-hr standard deviation of temperature was associated with longer QTc at moving averages from 4 and up to 28 days; a 1.9°C interquartile range increase in 4-day moving average standard deviation of temperature was associated with a 2.8 msec (95%CI: 0.4, 5.2) longer QTc. Associations between 24-hr standard deviation of temperature and QTc were stronger in colder months, and in participants with diabetes and coronary heart disease. CONCLUSION/SIGNIFICANCE: In this sample of older men, elevated mean temperature was associated with longer QTc, and increased variability of temperature was associated with longer QTc, particularly during colder months and among individuals with diabetes and coronary heart disease. These findings may offer insight of an important underlying mechanism of temperature-related cardiovascular morbidity and mortality in an older population.
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