Evidence map›Paper›PMID 25238130›Full record

ArticleLangmuir : the ACS journal of surfaces and colloids2014

Biocompatible nanoparticles of KGd(H₂O)₂[Fe(CN)₆]·H₂O with extremely high T₁-weighted relaxivity owing to two water molecules directly bound to the Gd(III) center.

Vindya S Perera, Liu D Yang, Jihua Hao, Guojun Chen, Bernadette O Erokwu, Chris A Flask, Peter Y Zavalij, James P Basilion, Songping D Huang

Open access · greenAbstract read
In one paragraph

Article in Langmuir : the ACS journal of surfaces and colloids, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. KCa(HAngewandte Chemie (International ed. in English) · 2018
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Vindya S PereraDepartment of Chemistry and Biochemistry, Kent State University , Kent, Ohio 44240, United States.
Liu D Yang
Jihua Hao
Guojun Chen
Bernadette O Erokwu
Chris A Flask
Peter Y Zavalij
James P Basilion
Songping D Huang
Kent State University · USCase Western Reserve University · USCase Comprehensive Cancer CenterUniversity of Maryland, College Park · US

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Prussian Blue Nanoparticles as Cellular T1 MRI Contrast AgentsR21CA143408 · NCI · KENT STATE UNIVERSITY · PI HUANG, SONGPING D · 2011 to 2013
$501k
NCATS NIH HHS UL1 TR000439NCI NIH HHS 1R21CA143408-01A1NCI NIH HHS R21 CA143408
6 · The paper itself

Abstract

A simple one-step method for preparing biocompatible nanoparticles of gadolinium ferrocyanide coordination polymer KGd(H2O)2[Fe(CN)6]·H2O is reported. The crystal structure of this coordination polymer is determined by X-ray powder diffraction using the bulk materials. The stability, cytotoxicity, cellular uptake, and MR phantom and cellular imaging studies suggest that this coordination-polymer structural platform offers a unique opportunity for developing the next generation of T1-weighted contrast agents with high relaxivity as cellular MR probes for biological receptors or markers. Such high-relaxivity MR probes may hold potential in the study of molecular events and may be used for in vivo MR imaging in biomedical research and clinical applications.

Indexed as

AnimalsBiocompatible MaterialsContrast MediaCoordination ComplexesCrystallography, X-RayFerrocyanidesGadoliniumHumansMagnetic Resonance ImagingMolecular ImagingNanoparticlesPhantoms, ImagingWaterBiocompatible MaterialsContrast MediaCoordination ComplexesFerrocyanidesGadoliniumWater

Identifiers

PMID25238130
PMCPMC4196746
OpenAlexW2335294980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.