Evidence map›Paper›PMID 25238093›Full record

ReviewImmunity2014

Development, differentiation, and diversity of innate lymphoid cells.

Andreas Diefenbach, Marco Colonna, Shigeo Koyasu

Abstract readReview
In one paragraph

Review in Immunity, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 339 papers.

0numbers the graph read from it
0cells of the map it votes in
339citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

339 citing papers in PubMed.

  1. Article
  2. Review
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  6. tRNA mCell discovery · 2026
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279 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Andreas DiefenbachResearch Centre for Immunology and Immunotherapy, University of Mainz Medical Centre, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany; Institute of Medical Microbiology and Hygiene, University of Mainz Medical Centre, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany. Electronic address: diefenbach@uni-mainz.de.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110, USA.
Shigeo KoyasuLaboratory for Immune Cell Systems, RIKEN Research Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan; Department of Microbiology and Immunology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan.

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
THE ROLE OF NK-22 CELLS IN ANTI-HIV-1 MUCOSAL IMMUNITYR01DE021255 · NIDCR · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2010 to 2014
$1.9M
CONTROLLING NK CELL ANTI-CANCER ACTIVITY: THE ROLE OF NUTRIENTS AND SUPPLEMENTSR21CA167192 · NCI · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2013 to 2014
$358k
NCI NIH HHS R21CA16719NCI NIH HHS R21 CA167192NIAID NIH HHS 1U01AI095542NIAID NIH HHS U01 AI095542NIDCR NIH HHS R01 DE021255NIDCR NIH HHS R01DE021255
6 · The paper itself

Abstract

Recent years have witnessed the discovery of an unprecedented complexity in innate lymphocyte lineages, now collectively referred to as innate lymphoid cells (ILCs). ILCs are preferentially located at barrier surfaces and are important for protection against pathogens and for the maintenance of organ homeostasis. Inappropriate activation of ILCs has been linked to the pathogenesis of inflammatory and autoimmune disorders. Recent evidence suggests that ILCs can be grouped into two separate lineages, cytotoxic ILCs represented by conventional natural killer (cNK) cells and cytokine-producing helper-like ILCs (i.e., ILC1s, ILC2s, ILC3s). We will focus here on current work in humans and mice that has identified core transcriptional circuitry required for the commitment of lymphoid progenitors to the ILC lineage. The striking similarities in transcriptional control of ILC and T cell lineages reveal important insights into the evolution of transcriptional programs required to protect multicellular organisms against infections and to fortify barrier surfaces.

Indexed as

AnimalsCell DifferentiationCell LineageCytokinesGene Expression RegulationHumansImmunity, InnateKiller Cells, NaturalMiceSignal TransductionStem CellsTight JunctionsT-Lymphocytes, Helper-InducerTranscription, GeneticCytokines

Identifiers

PMID25238093
PMCPMC4171710

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.