Evidence map›Paper›PMID 25237854›Full record

ArticleChemistry & biology2014

The expanding view of RNA and DNA function.

Ronald R Breaker, Gerald F Joyce

Open access · greenAbstract read
In one paragraph

Article in Chemistry & biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 109 citations in OpenAlex.

  1. Article
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  10. Alkyne Activation in the Diversity Oriented Synthesis of spChemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  11. Article
  12. Organic & biomolecular chemistry · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Ronald R BreakerDepartment of Molecular, Cellular and Developmental Biology, and Department of Molecular Biophysics and Biochemistry, Howard Hughes Medical Institute, Yale University, Box 208103, New Haven, CT 06520, USA. Electronic address: ronald.breaker@yale.edu.
Gerald F JoyceDepartment of Chemistry, The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 N. Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: gjoyce@scripps.edu.
Howard Hughes Medical Institute · USScripps Research Institute · US

Funding

Ligand-Dependent Exponential Amplification of RNAR01GM065130 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI JOYCE, GERALD F · 2002 to 2015
$4.1M
Howard Hughes Medical InstituteNIGMS NIH HHS R01 GM065130
6 · The paper itself

Abstract

RNA and DNA are simple linear polymers consisting of only four major types of subunits, and yet these molecules carry out a remarkable diversity of functions in cells and in the laboratory. Each newly discovered function of natural or engineered nucleic acids enforces the view that prior assessments of nucleic acid function were far too narrow and that many more exciting findings are yet to come. This Perspective highlights just a few of the numerous discoveries over the past 20 years pertaining to nucleic acid function, focusing on those that have been of particular interest to chemical biologists. History suggests that there will continue to be many opportunities to engage chemical biologists in the discovery, creation, and manipulation of nucleic acid function in the years to come.

Indexed as

Allosteric RegulationAptamers, NucleotideCatalysisDNADNA, CatalyticNucleic Acid ConformationRiboswitchRNARNA, CatalyticAptamers, NucleotideDNADNA, CatalyticRiboswitchRNARNA, Catalytic

Identifiers

PMID25237854
PMCPMC4171699
OpenAlexW2074374189

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.