Evidence map›Paper›PMID 25237829›Full record

SynthesisNutrients2014

Coffee consumption and risk of gastric cancer: a large updated meta-analysis of prospective studies.

Feiyue Xie, Dan Wang, Zhifang Huang, Yajun Guo

Abstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 6 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Coffee Consumption and Cancer Risk: An Assessment of the Health Implications Based on Recent Knowledge.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2021
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Feiyue XieThe Key Lab, Cancer Center, Chinese PLA General Hospital, Beijing 100853, China. Xiefeiyue123@163.com.
Dan WangSouth II Department, The General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China. wang_dan999@126.com.
Zhifang HuangDepartment of Rheumatology and Nephrology, Air Force General Hospital, Beijing 100142, China. huangzf_med@126.com.
Yajun GuoThe Key Lab, Cancer Center, Chinese PLA General Hospital, Beijing 100853, China. guoyjcc@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential role of coffee consumption in the development of various types of cancer has been extensively investigated in epidemiologic studies. How coffee consumption may modulate risk of gastric cancer, however, remains a subject open for investigation. To better quantify this relation, we quantitatively summarized evidence from prospective studies. Eligible studies were identified on PubMed and Embase databases. The summary risk estimates were obtained using the random-effects model. Subgroup, sensitivity and dose-response analyses were conducted. The present meta-analysis included 12 prospective cohort studies. A pooled analysis of these studies suggested that coffee consumption (highest vs. lowest consumption) was not associated with risk of gastric cancer (RR = 1.12, 95% CI = 0.93-1.36). In the subgroup analysis, significant increased risk was detected in the U.S. studies (RR = 1.36, 95% CI = 1.06-1.74) and in the studies with <10 years of follow-up (RR = 1.24, 95% CI = 1.00-1.54), and the greatest increase in risk was observed in those studies without adjustment for smoking (RR = 1.48, 95% CI = 1.13-1.93). There was some evidence of publication bias (P for Egger's test = 0.03). Cumulative evidence from prospective studies suggests that coffee consumption is not associated with risk of gastric cancer. The observed positive results may be confounded by smoking and need further investigation.

Indexed as

CoffeaCoffeeHumansSmokingStomach NeoplasmsCoffee

Identifiers

PMID25237829
PMCPMC4179186

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.