Evidence map›Paper›PMID 25237825›Full record

ReviewNature reviews. Molecular cell biology2014

Mitochondrial dynamics and inheritance during cell division, development and disease.

Prashant Mishra, David C Chan

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 566 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
566citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

566 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  17. Diffusive spreading across dynamic mitochondrial network architectures.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  18. Review
  19. Article
  20. Article

506 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Prashant MishraDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA.
David C Chan1] Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125, USA. [2] Howard Hughes Medical Institute, California Institute of Technology, Pasadena, California 91125, USA.

Funding

Mitochondrial Fusion: Analysis of Fzo FunctionR01GM062967 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHAN, DAVID C · 2001 to 2014
$3.7M
Analysis of Drp 1 Receptors Important for Mitochondrial FissionR01GM110039 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI CHAN, DAVID C · 2014 to 2017
$1.4M
Howard Hughes Medical InstituteNIGMS NIH HHS GM062967NIGMS NIH HHS GM110039NIGMS NIH HHS R01 GM062967NIGMS NIH HHS R01 GM110039
6 · The paper itself

Abstract

During cell division, it is critical to properly partition functional sets of organelles to each daughter cell. The partitioning of mitochondria shares some common features with that of other organelles, particularly in the use of interactions with cytoskeletal elements to facilitate delivery to the daughter cells. However, mitochondria have unique features - including their own genome and a maternal mode of germline transmission - that place additional demands on this process. Consequently, mechanisms have evolved to regulate mitochondrial segregation during cell division, oogenesis, fertilization and tissue development, as well as to ensure the integrity of these organelles and their DNA, including fusion-fission dynamics, organelle transport, mitophagy and genetic selection of functional genomes. Defects in these processes can lead to cell and tissue pathologies.

Indexed as

AnimalsCaenorhabditis elegansCell DivisionDrosophila melanogasterEmbryonic DevelopmentFertilizationHumansMitochondriaMitochondrial DynamicsMitophagyOogenesisSaccharomyces cerevisiae

Identifiers

PMID25237825
PMCPMC4250044

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.