Trial reportPloS one2014
Modafinil alters intrinsic functional connectivity of the right posterior insula: a pharmacological resting state fMRI study.
Trial report in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01684306 (Acute Effects of Modafinil on Brain Resting State Networks in Young Healthy Subjects), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Acute Effects of Modafinil on Brain Resting State Networks in Young Healthy Subjects
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Subacute changes in brain functional network connectivity after nocturnal sodium oxybate intake are associated with anterior cingulate GABA.Cerebral cortex (New York, N.Y. : 1991) · 2023Trial
- Cognitive enhancement: Effects of methylphenidate, modafinil, and caffeine on latent memory and resting state functional connectivity in healthy adults.Human brain mapping · 2022Trial
- The role of anterior and posterior insula in male genital response and in visual attention: an exploratory multimodal fMRI study.Scientific reports · 2020Trial
- Modafinil treatment modulates functional connectivity in stroke survivors with severe fatigue.Scientific reports · 2019Trial
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- The neuroreceptors and transporters underlying spontaneous brain activity.Communications biology · 2025Article
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- Effect of Modafinil on functional connectivity in healthy young people using resting-state fMRI data.American journal of neurodegenerative disease · 2022Article
- Dark Times: The Role of Negative Reinforcement in Methamphetamine Addiction.Frontiers in psychiatry · 2020Review
- The Insula: A Brain Stimulation Target for the Treatment of Addiction.Frontiers in pharmacology · 2019Review
- fMRIPrep: a robust preprocessing pipeline for functional MRI.Nature methods · 2019Article
- Modafinil-Induced Changes in Functional Connectivity in the Cortex and Cerebellum of Healthy Elderly Subjects.Frontiers in aging neuroscience · 2017Article
- Moral and social reasons to acknowledge the use of cognitive enhancers in competitive-selective contexts.BMC medical ethics · 2016Article
- Altered Brain Microstate Dynamics in Adolescents with Narcolepsy.Frontiers in human neuroscience · 2016Article
- Altered intra- and interregional synchronization in relapsing-remitting multiple sclerosis: a resting-state fMRI study.Neuropsychiatric disease and treatment · 2016Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModafinil is employed for the treatment of narcolepsy and has also been, off-label, used to treat cognitive dysfunction in neuropsychiatric disorders. In a previous study, we have reported that single dose administration of modafinil in healthy young subjects enhances fluid reasoning and affects resting state activity in the Fronto Parietal Control (FPC) and Dorsal Attention (DAN) networks. No changes were found in the Salience Network (SN), a surprising result as the network is involved in the modulation of emotional and fluid reasoning. The insula is crucial hub of the SN and functionally divided in anterior and posterior subregions. METHODOLOGY: Using a seed-based approach, we have now analyzed effects of modafinil on the functional connectivity (FC) of insular subregions. PRINCIPAL
findingsAnalysis of FC with resting state fMRI (rs-FMRI) revealed increased FC between the right posterior insula and the putamen, the superior frontal gyrus and the anterior cingulate cortex in the modafinil-treated group.
conclusionsModafinil is considered a putative cognitive enhancer. The rs-fMRI modifications that we have found are consistent with the drug cognitive enhancing properties and indicate subregional targets of action.
trial registrationClinicalTrials.gov NCT01684306.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.