Evidence map›Paper›PMID 25237629›Full record

ArticleTranslational andrology and urology2013

Androgen receptor genomic regulation.

Hong-Jian Jin, Jung Kim, Jindan Yu

Abstract read
In one paragraph

Article in Translational andrology and urology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 69 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
69citing papers in PubMed, 2 pooled it
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

69 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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  13. Small-molecule disruption of androgen receptor-dependent chromatin clusters.Proceedings of the National Academy of Sciences of the United States of America · 2024
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9 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Hong-Jian JinDivision of Hematology/Oncology, Department of Medicine, Chicago, IL 60611, USA.
Jung KimDivision of Hematology/Oncology, Department of Medicine, Chicago, IL 60611, USA.
Jindan YuDivision of Hematology/Oncology, Department of Medicine, Chicago, IL 60611, USA ; Robert H. Lurie Comprehensive Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
University of Chicago Medical Center · USRobert H. Lurie Comprehensive Cancer Center of Northwestern University

Funding

SUPPRESSIVE ROLE OF ANDROGEN RESPONSE GENE CALRETICULIN IN PROSTATE CANCERP50CA090386 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WANG, ZHOU · 2001 to 2013
$25.1M
TRANS-NETWORK PROJECTSU54CA143869 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PHILLIPS, ROB · 2009 to 2013
$12.8M
The Role of NOV (CCN3) in Prostate Cancer ProgressionR01CA172384 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YU, JINDAN · 2013 to 2017
$1.6M
The Role of beta-adrenergic Signaling in Prostate CancerR00CA129565 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI YU, JINDAN · 2010 to 2012
$732k
NCI NIH HHS P50 CA090386NCI NIH HHS R00 CA129565NCI NIH HHS R01 CA172384NCI NIH HHS U54 CA143869
6 · The paper itself

Abstract

The transcriptional activity of the androgen receptor (AR) is not only critical for the normal development and function of the prostate but also pivotal to the onset and progression of prostate cancer (PCa). The studies of AR transcriptional regulation were previously limited to a handful of AR-target genes. Owing to the development of various high-throughput genomic technologies, significant advances have been made in recent years. Here we discuss the discoveries of genome-wide androgen-regulated genes in PCa cell lines, animal models and tissues using expression microarray and sequencing, the mapping of genomic landscapes of AR using Combining Chromatin Immunoprecipitation (ChIP)-on-chip and ChIP-seq assays, the interplay of transcriptional cofactors in defining AR binding profiles, and the genomic regulation and AR reprogramming in advanced PCa.

Indexed as

Androgen receptor (AR)AR-target genesAR transcriptional regulationChIP-seq assaysCombining Chromatin Immunoprecipitation (ChIP)-on-chipprostate cancer (PCa)

Identifiers

PMID25237629
PMCPMC4165347
OpenAlexW2172809832

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.