ArticlePeerJ2014
Evidence that ebolaviruses and cuevaviruses have been diverging from marburgviruses since the Miocene.
Article in PeerJ, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Genomic transfers help to decipher the ancient evolution of filoviruses and interactions with vertebrate hosts.PLoS pathogens · 2024Article
- A novel approach to exploring the dark genome and its application to mapping of the vertebrate virus fossil record.Genome biology · 2024Article
- Roles of Human Endogenous Retroviruses and Endogenous Virus-Like Elements in Cancer Development and Innate Immunity.Biomolecules · 2023Review
- Phylogeography of Puumala orthohantavirus in Europe.Viruses · 2019Article
- Evolutionary persistence of insect bunyavirus infection despite host acquisition and expression of the viral nucleoprotein gene.Virus evolution · 2019Article
- Modeling site-specific amino-acid preferences deepens phylogenetic estimates of viral sequence divergence.Virus evolution · 2018Article
- Filoviruses: Ecology, Molecular Biology, and Evolution.Advances in virus research · 2018Review
- Putative endogenous filovirus VP35-like protein potentially functions as an IFN antagonist but not a polymerase cofactor.PloS one · 2017Article
- Bats and Emerging Infections: An Ecological and Virological Puzzle.Advances in experimental medicine and biology · 2017Article
- Review
- Integrated sequence and immunology filovirus database at Los Alamos.Database : the journal of biological databases and curation · 2016Article
- Filovirus receptor NPC1 contributes to species-specific patterns of ebolavirus susceptibility in bats.eLife · 2015Article
- Ebola in Antiquity?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2015Review
- Ebolavirus comparative genomics.FEMS microbiology reviews · 2015Review
- Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An understanding of the timescale of evolution is critical for comparative virology but remains elusive for many RNA viruses. Age estimates based on mutation rates can severely underestimate divergences for ancient viral genes that are evolving under strong purifying selection. Paleoviral dating, however, can provide minimum age estimates for ancient divergence, but few orthologous paleoviruses are known within clades of extant viruses. For example, ebolaviruses and marburgviruses are well-studied mammalian pathogens, but their comparative biology is difficult to interpret because the existing estimates of divergence are controversial. Here we provide evidence that paleoviral elements of two genes (ebolavirus-like VP35 and NP) in cricetid rodent genomes originated after the divergence of ebolaviruses and cuevaviruses from marburgviruses. We provide evidence of orthology by identifying common paleoviral insertion sites among the rodent genomes. Our findings indicate that ebolaviruses and cuevaviruses have been diverging from marburgviruses since the early Miocene.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.