ArticleJournal of gastrointestinal & digestive system2012
Polyamines and Gut Mucosal Homeostasis.
Article in Journal of gastrointestinal & digestive system, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
60 citing papers in PubMed, 79 citations in OpenAlex.
- Fecal calprotectin and gut microbiome in a cohort without intestinal pathologies from northern Italy.iScience · 2026Article
- Bismuth subsalicylate profoundly alters gut microbiome and immunity with increased susceptibility to infection.medRxiv : the preprint server for health sciences · 2025Article
- Innovative Approaches to Medical Rehabilitation: Regeneration, Immune Training, Homeostasis, and Microbiome Synergy.International journal of molecular sciences · 2025Review
- Article
- Gut-bone axis perturbation: Mechanisms and interventions via gut microbiota as a primary driver of osteoporosis.Journal of orthopaedic translation · 2025Review
- Arginase 2 attenuates ulcerative colitis by antioxidant effects of spermidine.Journal of gastroenterology · 2024Article
- The Roles of Polyamines in Intestinal Development and Function in Piglets.Animals : an open access journal from MDPI · 2024Review
- Microbiome Responses to Oral Fecal Microbiota Transplantation in a Cohort of Domestic Dogs.Veterinary sciences · 2024Article
- Regionalization of intestinal microbiota and metabolites in the small intestine of the Bactrian camel.Frontiers in immunology · 2024Article
- Impact of feed additives and host-related factors on bacterial metabolites, mucosal integrity and immune response in the ileum of broilers.Veterinary research communications · 2023Article
- The Effect ofDermatopathology (Basel, Switzerland) · 2023Article
- The Functional Roles of Methionine and Arginine in Intestinal and Bone Health of Poultry: Review.Animals : an open access journal from MDPI · 2023Review
- Digestibility and Palatability of the Diet and Intestinal Functionality of Dogs Fed a Blend of Yeast Cell Wall and Oregano Essential Oil.Animals : an open access journal from MDPI · 2023Article
- Mini-review: microbiota have potential to prevent PEDV infection by improved intestinal barrier.Frontiers in immunology · 2023Review
- Implication of gut microbes and its metabolites in colorectal cancer.Journal of cancer research and clinical oncology · 2023Review
- Food Peptides, Gut Microbiota Modulation, and Antihypertensive Effects.Molecules (Basel, Switzerland) · 2022Review
- Gut Microbiota Alterations in Trace Amine-Associated Receptor 9 (TAAR9) Knockout Rats.Biomolecules · 2022Article
- Ornithine Decarboxylase in Gastric Epithelial Cells Promotes the Immunopathogenesis ofJournal of immunology (Baltimore, Md. : 1950) · 2022Article
- Fate of undigested proteins in the pig large intestine: What impact on the colon epithelium?Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2022Review
- miR-195 regulates intestinal epithelial restitution after wounding by altering actin-related protein-2 translation.American journal of physiology. Cell physiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
The epithelium of gastrointestinal (GI) mucosa has the most rapid turnover rate of any tissue in the body and its integrity is preserved through the dynamic balance between cell migration, proliferation, growth arrest and apoptosis. To maintain tissue homeostasis of the GI mucosa, the rates of epithelial cell division and apoptosis must be highly regulated by various extracellular and intracellular factors including cellular polyamines. Natural polyamines spermidine, spermine and their precursor putrescine, are organic cations in eukaryotic cells and are implicated in the control of multiple signaling pathways and distinct cellular functions. Normal intestinal epithelial growth depends on the available supply of polyamines to the dividing cells in the crypts, and polyamines also regulate intestinal epithelial cell (IEC) apoptosis. Although the specific molecular processes controlled by polyamines remains to be fully defined, increasing evidence indicates that polyamines regulate intestinal epithelial integrity by modulating the expression of various growth-related genes. In this review, we will extrapolate the current state of scientific knowledge regarding the roles of polyamines in gut mucosal homeostasis and highlight progress in cellular and molecular mechanisms of polyamines and their potential clinical applications.
Indexed as
Identifiers
25237589PMC4165078W1986729205What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.