ArticleIranian Red Crescent medical journal2014
Methylenetetrahydrofolate Reductase C677T and A1298C Polymorphism in Iranian Women With Idiopathic Recurrent Pregnancy Losses.
Article in Iranian Red Crescent medical journal, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 30 citations in OpenAlex.
- Thrombophilic gene polymorphisms and recurrent pregnancy loss: a systematic review and meta-analysis.Journal of assisted reproduction and genetics · 2023Pooled it
- Association between gene polymorphism of folate metabolism and recurrent spontaneous abortion in Asia: A Meta-analysis.Medicine · 2020Pooled it
- Variants c.677 C>T, c.1298 A>C inGenetic testing and molecular biomarkers · 2020Article
- The interaction effect of angiogenesis and endothelial dysfunction-related gene variants increases the susceptibility of recurrent pregnancy loss.Journal of assisted reproduction and genetics · 2019Article
- Thrombophilia and Recurrent Pregnancy Loss: The Enigma Continues.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Association of parental methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in couples with unexplained recurrent pregnancy loss.BMC research notes · 2018Article
- Association between Thrombophilic Genes Polymorphisms and Recurrent Pregnancy Loss Susceptibility in the Iranian Population: a Systematic Review and Meta-AnalysisIranian biomedical journal · 2018Article
- Association of Factor V Leiden and Prothrombin G20210A Polymorphisms in Women with Recurrent Pregnancy Loss in Isfahan Province, Iran.International journal of preventive medicine · 2018Article
- Methylenetetrahydrofolate Reductase Polymorphisms and Risk of Recurrent Pregnancy Loss: a Case-Control Study.Journal of Korean medical science · 2017Article
- Methylenetetrahydrofolate Reductase C677T Polymorphism and Recurrent Pregnancy Loss Risk in Asian Population: A Meta-analysis.Indian journal of clinical biochemistry : IJCB · 2016Article
- Association of the methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism with primary glaucoma in Saudi population.BMC ophthalmology · 2016Article
- Etiologic characteristics and index pregnancy outcomes of recurrent pregnancy losses in Korean women.Obstetrics & gynecology science · 2016Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecurrent pregnancy loss (RPL) is a serious problem for pregnancy. There is evidence that vascular complications play a principal role in RPL. Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme in folate metabolism. Polymorphisms (C677T, A1298C) of MTHFR gene are associated with decreased MTHFR activity.
objectivesThe aim of this study was to determine the association between MTHFR polymorphisms (C677T and A1298C) and recurrent pregnancy loss (RPL) in Iranian women. MATERIALS AND
methodsIn this case-control study, blood samples were obtained from patients who had three or more consecutive pregnancy losses before the 22(nd) week of pregnancy (n = 204). The control group consisted of 116 age-matched women with at least one alive child and without any history of pregnancy loss or other gestational complications (n = 116). Following DNA extraction, samples were tested for MTHFR C677T and A1298C polymorphisms using the reverse hybridization method.
resultsThe prevalence of 677TT mutation was 8.8% (18/204) in the patient group and 8.6% (10/116) in the control group (P = 0.434). The prevalence of 1298CC mutation was 12.3 % (25/204) in the patient group and 8% (9/116) in the control group (P = 0.155). Investigation of the distributions of various genotypes of MTHFR C677T and A1298C did not indicate a significant difference between patients with RPL and healthy control subjects.
conclusionsThe results suggest that MTHFR mutations might not be associated with RPL in the examined population.
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