ArticleJournal of flow chemistry2011
An Automated Process for a Sequential Heterocycle/Multicomponent Reaction: Multistep Continuous Flow Synthesis of 5-(Thiazol-2-yl)-3,4-Dihydropyrimidin-2(
Article in Journal of flow chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed.
- Progress in Continuous Flow Synthesis of Hydrogen-Bonded Organic Framework Material Synthons.Molecules (Basel, Switzerland) · 2024Review
- A Combination of Flow and Batch Mode Processes for the Efficient Preparation of mGluTetrahedron · 2018Article
- Assessing the possibilities of designing a unified multistep continuous flow synthesis platform.Beilstein journal of organic chemistry · 2018Review
- An integrated chemical biology approach reveals the mechanism of action of HIV replication inhibitors.Bioorganic & medicinal chemistry · 2017Article
- Synthesis of α-amino-1,3-dicarbonyl compounds via Ugi flow chemistry reaction: access to functionalized 1,2,3-triazoles.Molecular diversity · 2017Article
- Continuous-flow synthesis of highly functionalized imidazo-oxadiazoles facilitated by microfluidic extraction.Beilstein journal of organic chemistry · 2017Article
- Raman spectroscopy as a tool for monitoring mesoscale continuous-flow organic synthesis: Equipment interface and assessment in four medicinally-relevant reactions.Beilstein journal of organic chemistry · 2013Article
- Automated Multistep Continuous Flow Synthesis of 2-(Synthesis · 2012Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The first example of a sequential heterocycle formation/multicomponent reaction using an automated continuous flow microreactor assembly is reported. Consecutive Hantzsch thiazole synthesis, deketalization, and Biginelli multicomponent reaction provides rapid and efficient access to highly functionalized, pharmacologically significant 5-(thiazol-2-yl)-3,4-dihydropyrimidin-2(
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Registered trials
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