Evidence map›Paper›PMID 25237463›Full record

Trial reportKorean journal of urology2014

Effect of improvement in lower urinary tract symptoms on sexual function in men: tamsulosin monotherapy vs. combination therapy of tamsulosin and solifenacin.

Kyungtae Ko, Dae Yul Yang, Won Ki Lee, Sae Woong Kim, Du Geon Moon, Ki Hak Moon, Nam Cheol Park, Jong Kwan Park, Hwan Cheol Son, Sung Won Lee and 2 more

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Korean journal of urology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 3 pooled it
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 3 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 2 countries.

Kyungtae KoDepartment of Urology, Hallym University College of Medicine, Chuncheon, Korea.
Dae Yul YangDepartment of Urology, Hallym University College of Medicine, Chuncheon, Korea.
Won Ki LeeDepartment of Urology, Hallym University College of Medicine, Chuncheon, Korea.
Sae Woong KimDepartment of Urology, The Catholic University College of Medicine, Seoul, Korea.
Du Geon MoonDepartment of Urology, Korea University College of Medicine, Seoul, Korea.
Ki Hak MoonDepartment of Urology, Yeungnam University College of Medicine, Daegu, Korea.
Nam Cheol ParkDepartment of Urology, Pusan National University School of Medicine, Busan, Korea.
Jong Kwan ParkDepartment of Urology, Chonbuk National University Medical School, Jeonju, Korea.
Hwan Cheol SonDepartment of Urology, Seoul National University College of Medicine, Seoul, Korea.
Sung Won LeeDepartment of Urology, Sungkyunkwan University School of Medicine, Seoul, Korea.
Jae Seog HyunDepartment of Urology, Gyeongsang National University School of Medicine, Jinju, Korea.
Kwangsung ParkDepartment of Urology, Chonnam National University Medical School, Gwangju, Korea.
Hallym University · KRCatholic University of Korea · KRChonnam National University Hospital · KRGyeongsang National University · KRJeonbuk National University · KRKorea University · KRPusan National University · KRSeoul National University · KRSungkyunkwan University · KRYeungnam University College

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate how much the improvement of lower urinary tract symptoms (LUTS) affects sexual function and which storage symptoms or voiding symptoms have the greatest effect on sexual function. MATERIALS AND

methodsA total of 187 patients were enrolled in this study. Patients were randomly assigned to receive either tamsulosin 0.2 mg (group A) or tamsulosin 0.2 mg and solifenacin 5 mg (group B). At 4 weeks and 12 weeks, the LUTS and sexual function of the patients were evaluated by use of the International Index of Erectile Function-5 (IIEF5), International Prostate Symptom Score (IPSS), Overactive Bladder Symptom Score (OABSS) questionnaire, uroflowmetry, and bladder scan.

resultsBoth groups A and B showed statistically significant improvements in IPSS, OABSS, and quality of life (QoL). Group A showed improved maximum flow rate, mean flow rate, and residual urine volume by time. Group B did not show an improvement in flow rate or residual urine volume but total voiding volume increased with time. The IIEF5 score was not improved in either group. In group A, the IIEF5 score dropped from 13.66 ± 4.97 to 11.93 ± 6.14 after 12 weeks (p=0.072). Group B showed a decline in the IIEF5 score from 13.19 ± 5.91 to 12.45 ± 6.38 (p=0.299). Although group B showed a relatively smaller decrease in the IIEF5 score, the difference between the two groups was not significant (p=0.696).

conclusionsTamsulosin monotherapy and combination therapy with solifenacin did not improve erectile function despite improvements in voiding symptoms and QoL. The improvement in storage symptoms did not affect erectile function.

Indexed as

AgedDrug Therapy, CombinationErectile DysfunctionHumansLower Urinary Tract SymptomsMaleMiddle AgedQuality of LifeQuinuclidinesRheologySolifenacin SuccinateSulfonamidesSurveys and QuestionnairesTamsulosinTetrahydroisoquinolinesTreatment OutcomeQuinuclidinesSolifenacin SuccinateSulfonamidesTamsulosinTetrahydroisoquinolinesUrological AgentsErectile dysfunctionLower urinary tract symptomsOveractive urinary bladder

Identifiers

PMID25237463
PMCPMC4165924
OpenAlexW1967030306

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.