ArticleIranian journal of pharmaceutical research : IJPR2014
Anti-Viral Evaluation of Sesquiterpene Coumarins from Ferula assa-foetida against HSV-1.
Article in Iranian journal of pharmaceutical research : IJPR, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Antiviral Effect ofCurrent pharmaceutical biotechnology · 2025Review
- Antiviral activity ofIranian journal of microbiology · 2024Article
- Sesquiterpenes and Sesquiterpene Derivatives fromAntioxidants (Basel, Switzerland) · 2023Review
- Critical Review on Nutritional, Bioactive, and Medicinal Potential of Spices and Herbs and Their Application in Food Fortification and Nanotechnology.Applied biochemistry and biotechnology · 2023Review
- Article
- Therapeutic potential of Ferula foetida(Bunge) Regel on gastric ulcer model in rats.Environmental science and pollution research international · 2022Article
- Pharmacological perspectives and molecular mechanisms of coumarin derivatives against virus disease.Genes & diseases · 2022Review
- Antiviral Plants in View of Avicenna's The Canon of Medicine and Modern Medicine Against Common Cold.Advances in experimental medicine and biology · 2021Article
- Culinary spice bioactives as potential therapeutics against SARS-CoV-2: Computational investigation.Computers in biology and medicine · 2021Article
- Natural Products-Derived Chemicals: Breaking Barriers to Novel Anti-HSV Drug Development.Viruses · 2020Review
- Metabolic Profile, Bioactivities, and Variations in the Chemical Constituents of Essential Oils of theFrontiers in pharmacology · 2020Review
- Review
- Therapeutic potential of coumarins as antiviral agents.European journal of medicinal chemistry · 2016Review
- Comparative Evaluation of Cytotoxic and Apoptogenic Effects of Several Coumarins on Human Cancer Cell Lines: Osthole Induces Apoptosis in p53-Deficient H1299 Cells.Advances in pharmacological sciences · 2014Article
- The effect of hydroalcoholic extract of Ferula foetida stems on blood pressure and oxidative stress in dexamethasone-induced hypertensive rats.Research in pharmaceutical sciencesArticle
- In vitro Evaluation of the Potent Antileishmanial Activity ofIranian journal of pharmaceutical research : IJPRArticle
- Cytotoxic activity of the genusAvicenna journal of phytomedicineReview
- Effect of Ferula assa-foetida oleo gum resin on spermatic parameters and testicular histopathology in male wistar rats.Journal of Ayurveda and integrative medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several complications attributed with Herpes virus related infections and the emergence of drug resistant viruses prompt scientists to search for new drugs. Several terpenoids and coumarins have shown anti HSV effects while no sesquiterpene coumarins have been previously tested for HSV treatment. Three sesquiterpene coumarins badrakemin acetate (1), kellerin (2) and samarcandin diastereomer (3) were isolated from the gum resin of Ferula assa-foetida, a herbal medicine with antimicrobial, antiprotozoal and antiviral effects. Compounds were identified by 1D and 2D- NMR spectroscopies and comparison with literature data. A comparative evaluation of cytotoxicity and antiviral activity showed that kellerin (2) could significantly inhibit the cytopathic effects and reduce the viral titre of the herpes virus type 1 (HSV-1) DNA viral strain KOS at concentrations of 10, 5 and 2.5 µg/mL.
Indexed as
Identifiers
25237347PMC4157027W2106650244What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.