ArticleFrontiers in cellular neuroscience2014
Differential contribution of TRPM4 and TRPM5 nonselective cation channels to the slow afterdepolarization in mouse prefrontal cortex neurons.
Article in Frontiers in cellular neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 46 citations in OpenAlex.
- Cell-type-specific cholinergic control of granular retrosplenial cortex with implications for angular velocity coding across brain states.Progress in neurobiology · 2025Article
- Cholinergic stimulation stabilizes TRPM4 in the plasma membrane of cortical pyramidal neurons.Frontiers in cell and developmental biology · 2024Article
- Short-term Hebbian learning can implement transformer-like attention.PLoS computational biology · 2024Article
- Article
- Impaired muscarinic modulation of the rat prelimbic cortex in neuropathic pain is sexually dimorphic and associated with cold allodynia.Frontiers in cellular neuroscience · 2023Article
- IInternational journal of molecular sciences · 2021Article
- TRPM4 mediates a subthreshold membrane potential oscillation in respiratory chemoreceptor neurons that drives pacemaker firing and breathing.Cell reports · 2021Article
- Distribution and Assembly of TRP Ion Channels.Advances in experimental medicine and biology · 2021Article
- TRPM4 Expression During Postnatal Developmental of Mouse CA1 Pyramidal Neurons.Frontiers in neuroanatomy · 2021Article
- TRPM4 Conductances in Thalamic Reticular Nucleus Neurons Generate Persistent Firing during Slow Oscillations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Parameter tuning differentiates granule cell subtypes enriching transmission properties at the cerebellum input stage.Communications biology · 2020Article
- Involvement of TRPC4 and 5 Channels in Persistent Firing in Hippocampal CA1 Pyramidal Cells.Cells · 2020Article
- TRPC channels are not required for graded persistent activity in entorhinal cortex neurons.Hippocampus · 2019Article
- Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Mechanisms Underlying Serotonergic Excitation of Callosal Projection Neurons in the Mouse Medial Prefrontal Cortex.Frontiers in neural circuits · 2018Article
- Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.Frontiers in cellular neuroscience · 2018Article
- Mechanisms of Persistent Activity in Cortical Circuits: Possible Neural Substrates for Working Memory.Annual review of neuroscience · 2017Review
- Loss of M1 Receptor Dependent Cholinergic Excitation Contributes to mPFC Deactivation in Neuropathic Pain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- A unifying hypothesis for M1 muscarinic receptor signalling in pyramidal neurons.The Journal of physiology · 2017Article
- Ionic mechanisms maintaining action potential conduction velocity at high firing frequencies in an unmyelinated axon.Physiological reports · 2016Article
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
In certain neurons from different brain regions, a brief burst of action potentials can activate a slow afterdepolarization (sADP) in the presence of muscarinic acetylcholine receptor agonists. The sADP, if suprathreshold, can contribute to persistent non-accommodating firing in some of these neurons. Previous studies have characterized a Ca(2+)-activated non-selective cation (CAN) current (ICAN ) that is thought to underlie the sADP. ICAN depends on muscarinic receptor stimulation and exhibits a dependence on neuronal activity, membrane depolarization and Ca(2+)-influx similar to that observed for the sADP. Despite the widespread occurrence of sADPs in neurons throughout the brain, the molecular identity of the ion channels underlying these events, as well as ICAN , remains uncertain. Here we used a combination of genetic, pharmacological and electrophysiological approaches to characterize the molecular mechanisms underlying the muscarinic receptor-dependent sADP in layer 5 pyramidal neurons of mouse prefrontal cortex. First, we confirmed that in the presence of the cholinergic agonist carbachol a brief burst of action potentials triggers a prominent sADP in these neurons. Second, we confirmed that this sADP requires activation of a PLC signaling cascade and intracellular calcium signaling. Third, we obtained direct evidence that the transient receptor potential (TRP) melastatin 5 channel (TRPM5), which is thought to function as a CAN channel in non-neural cells, contributes importantly to the sADP in the layer 5 neurons. In contrast, the closely related TRPM4 channel may play only a minor role in the sADP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.