ArticleTropical medicine and health2014
Ascaris lumbricoids Infection as a Risk Factor for Asthma and Atopy in Rural Bangladeshi Children.
Article in Tropical medicine and health, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Risk factors of asthma in the Asian population: a systematic review and meta-analysis.Journal of physiological anthropology · 2021Pooled it
- Evaluation of Total Serum IgE Level and Associated Factors in Asthmatic Patients at the University of Gondar Hospital, Northwest Ethiopia: A Comparative Cross-Sectional Study.Health science reports · 2026Article
- Single-cell molecular signature of pathogenic T helper subsets in type 2-associated disorders in humans.JCI insight · 2024Article
- Microbes little helpers and suppliers for therapeutic asthma approaches.Respiratory research · 2024Review
- Elevated circulating group-2 innate lymphoid cells expressing activation markers and correlated tryptase AB1 levels in active ascariasis.Frontiers in immunology · 2024Article
- Tissue-specific immunity in helminth infections.Mucosal immunology · 2022Review
- Editorial: Translational research in pediatric respiratory diseases: From bench to bedside.Frontiers in pediatrics · 2022Article
- Intestinal helminthic infection and allergic disorders among school children enrolled in mass deworming program, Sululta, Ethiopia.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2021Article
- Impact of Haemophilus influenzae type b combination vaccination on asthma symptoms and pneumonia in 5-year-old children in rural Bangladesh: a longitudinal study and comparison with a previous cross-sectional study.Respiratory research · 2021Article
- Soil-transmitted helminthiasis in four districts in Bangladesh: household cluster surveys of prevalence and intervention status.BMC public health · 2020Article
- What Can Parasites Tell Us About the Pathogenesis and Treatment of Asthma and Allergic Diseases.Frontiers in immunology · 2020Review
- G Protein-Coupled Receptors in Asthma Therapy: Pharmacology and Drug Action.Pharmacological reviews · 2020Review
- Exposure to Ascaris lumbricoides infection and risk of childhood asthma in north of Iran.Infection · 2019Article
- Concurrent decreases in the prevalence of wheezing and Ascaris infection among 5-year-old children in rural Bangladesh and their regulatory T cell immunity after the implementation of a national deworming program.Immunity, inflammation and disease · 2019Article
- Classification of Wheezing Children in Rural Bangladesh by Intensity ofJournal of immunology research · 2019Article
- Article
- Maternal Micronutrient Supplementation and Long Term Health Impact in Children in Rural Bangladesh.PloS one · 2016Article
- Comment on IgE responses to Ascaris and mite tropomyosins are risk factors for asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 4 countries.
Funding
Abstract
Controversy persists as to whether helminth infections cause or protect against asthma and atopy. The aim of this study was to investigate the effects of helminth infection on asthma and atopy among Bangladeshi children. A total of 912 children aged 4.5 years (mean = 54.4, range = 53.5-60.8 months) participated in a cross-sectional study nested into a randomized controlled trial in Bangladesh. Ever-asthma, ever-wheezing and current wheezing were identified using the International Study of Asthma and Allergies in Childhood questionnaire. Current helminth infection was defined by the presence of helminth eggs in stools, measured by routine microscopic examination. Repeated Ascaris infection was defined by the presence of anti-Ascaris IgE ≥ 0.70 UA/ml in serum measured by the CAP-FEIA method. Atopy was defined by specific IgE to house dust mite (anti-DP IgE) ≥ 0.70 UA/ml measured by the CAP-FEIA method and/or positive skin prick test (≥ 5 mm). Anti-Ascaris IgE was significantly associated with ever asthma (odds ratio (OR) = 1.86, 95% CI: 1.14-3.04, highest vs. lowest quartile; P for trend 0.016). Anti-Ascaris IgE was also significantly associated with positive anti-DP IgE (OR = 9.89, 95% CI: 6.52-15.00, highest vs. lowest; P for trend < 0.001) and positive skin prick test (OR = 1.69, 95% CI: 1.01-2.81, highest vs. lowest, P for trend 0.076). These findings suggest that repeated Ascaris infection is a risk factor for asthma and atopy in rural Bangladeshi children. Further analysis is required to examine the mechanism of developing asthma and atopy in relation to helminth infection.
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Registered trials
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