ArticlePlant physiology2014
Pepper mitochondrial FORMATE DEHYDROGENASE1 regulates cell death and defense responses against bacterial pathogens.
Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 42 citations in OpenAlex.
- Mitochondrial formate dehydrogenase links mitochondrial and cytosolic one carbon metabolism via a one-carbon shunt.Plant physiology · 2026Review
- Hijacking host metabolism: PstEXLX1 suppresses Triticum aestivum defense responses by targeting a formate dehydrogenase.Plant physiology · 2025Article
- Redox dynamics in seeds ofFrontiers in plant science · 2024Article
- The formate dehydrogenase enhances aluminum tolerance of tobacco.Journal of genetics · 2023Article
- Review
- Dynamic Transcriptome Profiling of Mungbean Genotypes Unveil the Genes Respond to the Infection of Mungbean Yellow Mosaic Virus.Pathogens (Basel, Switzerland) · 2022Article
- Functional role of formate dehydrogenase 1 (FDH1) for host and nonhost disease resistance against bacterial pathogens.PloS one · 2022Article
- What Do We Know About the Genetic Basis of Seed Desiccation Tolerance and Longevity?International journal of molecular sciences · 2020Review
- Proteomic analysis upon peach fruit infection with Monilinia fructicola and M. laxa identify responses contributing to brown rot resistance.Scientific reports · 2020Article
- Matrix Redox Physiology Governs the Regulation of Plant Mitochondrial Metabolism through Posttranslational Protein Modifications.The Plant cell · 2020Review
- Seed comparative genomics in three coffee species identify desiccation tolerance mechanisms in intermediate seeds.Journal of experimental botany · 2020Article
- The plant pathogen Pectobacterium atrosepticum contains a functional formate hydrogenlyase-2 complex.Molecular microbiology · 2019Article
- Analysis of metabolic pathways related to fertility restoration and identification of fertility candidate genes associated with Aegilops kotschyi cytoplasm in wheat (Triticum aestivum L.).BMC plant biology · 2019Article
- Fine mapping and candidate gene analysis of the quantitative trait locus gw8.1 associated with grain length in rice.Genes & genomics · 2018Article
- Degradation of the stress-responsive enzyme formate dehydrogenase by the RING-type E3 ligase Keep on Going and the ubiquitin 26S proteasome system.Plant molecular biology · 2018Article
- Proteomics and functional analyses of Arabidopsis nitrilases involved in the defense response to microbial pathogens.Planta · 2016Article
- A Formate Dehydrogenase Confers Tolerance to Aluminum and Low pH.Plant physiology · 2016Article
- Article
- Isolation and Characterization of Pepper Genes Interacting with the CMV-P1 Helicase Domain.PloS one · 2016Article
- The mitochondrial malate dehydrogenase 1 gene GhmMDH1 is involved in plant and root growth under phosphorus deficiency conditions in cotton.Scientific reports · 2015Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formate dehydrogenase (FDH; EC 1.2.1.2) is an NAD-dependent enzyme that catalyzes the oxidation of formate to carbon dioxide. Here, we report the identification and characterization of pepper (Capsicum annuum) mitochondrial FDH1 as a positive regulator of cell death and defense responses. Transient expression of FDH1 caused hypersensitive response (HR)-like cell death in pepper and Nicotiana benthamiana leaves. The D-isomer -: specific 2-hydroxyacid dehydrogenase signatures of FDH1 were required for the induction of HR-like cell death and FDH activity. FDH1 contained a mitochondrial targeting sequence at the N-terminal region; however, mitochondrial localization of FDH1 was not essential for the induction of HR-like cell death and FDH activity. FDH1 silencing in pepper significantly attenuated the cell death response and salicylic acid levels but stimulated growth of Xanthomonas campestris pv vesicatoria. By contrast, transgenic Arabidopsis (Arabidopsis thaliana) overexpressing FDH1 exhibited greater resistance to Pseudomonas syringae pv tomato in a salicylic acid-dependent manner. Arabidopsis transfer DNA insertion mutant analysis indicated that AtFDH1 expression is required for basal defense and resistance gene-mediated resistance to P. syringae pv tomato infection. Taken together, these data suggest that FDH1 has an important role in HR-like cell death and defense responses to bacterial pathogens.
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