Evidence map›Paper›PMID 25237060›Full record

ArticleToxicological sciences : an official journal of the Society of Toxicology2014

Epigenetic events determine tissue-specific toxicity of inhalational exposure to the genotoxic chemical 1,3-butadiene in male C57BL/6J mice.

Grace Chappell, Tetyana Kobets, Bridget O'Brien, Natalia Tretyakova, Dewakar Sangaraju, Oksana Kosyk, Kenneth G Sexton, Wanda Bodnar, Igor P Pogribny, Ivan Rusyn

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicological sciences : an official journal of the Society of Toxicology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Commentary: Novel strategies and new tools to curtail the health effects of pesticides.Environmental health : a global access science source · 2021
    Article
  4. An Assessment on Ethanol-Blended Gasoline/Diesel Fuels on Cancer Risk and Mortality.International journal of environmental research and public health · 2021
    Review
  5. Article
  6. Article
  7. Article
  8. Tissue- and strain-specific effects of a genotoxic carcinogen 1,3-butadiene on chromatin and transcription.Mammalian genome : official journal of the International Mammalian Genome Society · 2018
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Response of transposable elements to environmental stressors.Mutation research. Reviews in mutation research
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Grace Chappell*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Tetyana Kobets*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 *Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Bridget O'Brien*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Natalia Tretyakova*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Dewakar Sangaraju*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Oksana Kosyk*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Kenneth G Sexton*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Wanda Bodnar*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Igor P Pogribny*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455.
Ivan Rusyn*Department of Environmental Sciences and Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, Division of Biochemical Toxicology, National Center for Toxicological Research, FDA, Jefferson, Arkansas 72079 and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 iir@unc.edu.
University of North Carolina at Chapel Hill · USUnited States Food and Drug Administration · US

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
UNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Melissa A. Troester · 2001 to 2026
$36.3M
Genes, genomes, and genotoxicity: in vivo epigenetic toxicology of 1,3-butadieneR01ES023195 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI CRAWFORD, GREGORY E, FUREY, TERRENCE S. · 2013 to 2016
$2.2M
NCI NIH HHS P30 CA077598NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES023195
6 · The paper itself

Abstract

1,3-Butadiene (BD), a widely used industrial chemical and a ubiquitous environmental pollutant, is a known human carcinogen. Although genotoxicity is an established mechanism of the tumorigenicity of BD, epigenetic effects have also been observed in livers of mice exposed to the chemical. To better characterize the diverse molecular mechanisms of BD tumorigenicity, we evaluated genotoxic and epigenotoxic effects of BD exposure in mouse tissues that are target (lung and liver) and non-target (kidney) for BD-induced tumors. We hypothesized that epigenetic alterations may explain, at least in part, the tissue-specific differences in BD tumorigenicity in mice. We evaluated the level of N-7-(2,3,4-trihydroxybut-1-yl)guanine adducts and 1,4-bis-(guan-7-yl)-2,3-butanediol crosslinks, DNA methylation, and histone modifications in male C57BL/6 mice exposed to filtered air or 425 ppm of BD by inhalation (6 h/day, 5 days/week) for 2 weeks. Although DNA damage was observed in all three tissues of BD-exposed mice, variation in epigenetic effects clearly existed between the kidneys, liver, and lungs. Epigenetic alterations indicative of genomic instability, including demethylation of repetitive DNA sequences and alterations in histone-lysine acetylation, were evident in the liver and lung tissues of BD-exposed mice. Changes in DNA methylation were insignificant in the kidneys of treated mice, whereas marks of condensed heterochromatin and transcriptional silencing (histone-lysine trimethylation) were increased. These modifications may represent a potential mechanistic explanation for the lack of tumorigenesis in the kidney. Our results indicate that differential tissue susceptibility to chemical-induced tumorigenesis may be attributed to tissue-specific epigenetic alterations.

Indexed as

DNA AdductsAir PollutantsAnimalsBlotting, WesternButadienesCarcinogens, EnvironmentalDNA MethylationEpigenesis, GeneticGenomic InstabilityHistonesInhalation ExposureKidneyLiverLungMaleMice, Inbred C57BL1,3-butadieneAir PollutantsButadienesCarcinogens, EnvironmentalDNA AdductsHistones1,3-butadieneepigeneticsgenotoxicity

Identifiers

PMID25237060
PMCPMC4250847
OpenAlexW2001922348

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.