ArticleNucleic acids research2014
Silkworm HP1a transcriptionally enhances highly expressed euchromatic genes via association with their transcription start sites.
Article in Nucleic acids research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 16 citations in OpenAlex.
- Genome-wide mapping of theiScience · 2026Article
- The piRNA cluster torimochi is an expanding transposon in cultured silkworm cells.PLoS genetics · 2023Article
- Article
- SilkBase: an integrated transcriptomic and genomic database for Bombyx mori and related species.Database : the journal of biological databases and curation · 2022Article
- H3K4me3 histone modification in baculovirus-infected silkworm cells.Virus genes · 2021Article
- High-QualityFrontiers in genetics · 2021Article
- Dynamic chromatin accessibility profiling reveals changes in host genome organization in response to baculovirus infection.PLoS pathogens · 2020Article
- Transcriptome profiling reveals infection strategy of an insect maculavirus.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- BmncRNAdb: a comprehensive database of non-coding RNAs in the silkworm, Bombyx mori.BMC bioinformatics · 2016Article
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterochromatin protein 1 (HP1) is an evolutionarily conserved protein across different eukaryotic species and is crucial for heterochromatin establishment and maintenance. The silkworm, Bombyx mori, encodes two HP1 proteins, BmHP1a and BmHP1b. In order to investigate the role of BmHP1a in transcriptional regulation, we performed genome-wide analyses of the transcriptome, transcription start sites (TSSs), chromatin modification states and BmHP1a-binding sites of the silkworm ovary-derived BmN4 cell line. We identified a number of BmHP1a-binding loci throughout the silkworm genome and found that these loci included TSSs and frequently co-occurred with neighboring euchromatic histone modifications. In addition, we observed that genes with BmHP1a-associated TSSs were relatively highly expressed in BmN4 cells. RNA interference-mediated BmHP1a depletion resulted in the transcriptional repression of highly expressed genes with BmHP1a-associated TSSs, whereas genes not coupled with BmHP1a-binding regions were less affected by the treatment. These results demonstrate that BmHP1a binds near TSSs of highly expressed euchromatic genes and positively regulates their expression. Our study revealed a novel mode of transcriptional regulation mediated by HP1 proteins.
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