Evidence map›Paper›PMID 25237045›Full record

Observational studyJournal of the American Heart Association2014

The early stage of the atrial electroanatomic remodeling as substrates for atrial fibrillation in hypertensive patients.

Xiaomeng Yin, Yan Zhao, Yutao Xi, Nancy Cheng, Yunlong Xia, Shulong Zhang, Yingxue Dong, Dong Chang, Jie Cheng, Yanzong Yang and 1 more

Erratum issuedOpen access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of the American Heart Association, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Xiaomeng YinFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.) Texas Heart Institute/St Luke's Hospital, Houston, TX (X.Y., Y.X., N.C., J.C.).
Yan ZhaoFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Yutao XiTexas Heart Institute/St Luke's Hospital, Houston, TX (X.Y., Y.X., N.C., J.C.) Section of Cardiology, University of Texas School of Medicine at Houston, Houston, TX (Y.X., J.C.).
Nancy ChengTexas Heart Institute/St Luke's Hospital, Houston, TX (X.Y., Y.X., N.C., J.C.).
Yunlong XiaFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Shulong ZhangFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Yingxue DongFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Dong ChangFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Jie ChengTexas Heart Institute/St Luke's Hospital, Houston, TX (X.Y., Y.X., N.C., J.C.) Section of Cardiology, University of Texas School of Medicine at Houston, Houston, TX (Y.X., J.C.).
Yanzong YangFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
Lianjun GaoFirst Affiliated Hospital of Dalian Medical University, Dalian, Liaoning, China (X.Y., Y.Z., Y.X., S.Z., Y.D., D.C., Y.Y., L.G.).
First Affiliated Hospital of Dalian Medical University · CNDalian Medical University · CNSt. Luke's Hospital · USThe University of Texas Health Science Center at Houston · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHypertension is one of the most important risk factors for atrial fibrillation (AF). Recent studies suggest right atrial remodeling in hypertensive patients may be associated with increased inducibility of AF. This study sought to characterize the electroanatomic features of left and right atria and pulmonary veins (PVs) in hypertensive patients. METHODS AND

resultsA prospective observational study was conducted on patients who underwent ablation for paroxysmal supraventricular tachycardia or paroxysmal AF. Electrophysiological features of the PVs and atria, including event-related potentials, conduction time, and inducibility and vulnerability of AF, were characterized during cardiac catheterization. Anatomic and hemodynamic features were assessed by using echocardiographic and computer tomography imaging. When 15 hypertensive patients with paroxysmal supraventricular tachycardia were compared with 17 normotensive patients with paroxysmal supraventricular tachycardia, the hypertensive patients had significantly shortened PV event-related potentials with increased dispersions (P<0.001) but slightly prolonged atrial event-related potentials (P=NS) and had prolonged interatrial and intra-atrial conduction times (P<0.001). Additionally, the hypertensive patients had increased vulnerability and inducibility of AF and prolonged duration of induced AF (P<0.01). All of these changes were more pronounced in hypertensive patients with paroxysmal AF. Anatomically, compared with the normotensive patients, the diameters of 4 PVs in the hypertensive patients with paroxysmal supraventricular tachycardia were significantly enlarged (P<0.01) and became more remarkable in hypertensive patients with paroxysmal AF (P<0.0001), although the diameter and volume index of the left atrium among 3 groups were similar.

conclusionsThe hypertensive patients showed electroanatomic changes associated with increased vulnerability to AF, including shortened event-related potentials with increased dispersion, prolonged conduction time, and increased PV diameter, but these changes were not appreciated in the atria. Additionally, these changes became more dramatic in hypertensive patients with paroxysmal AF.

Indexed as

Atrial RemodelingAction PotentialsAgedAtrial FibrillationCase-Control StudiesCatheter AblationElectrocardiographyElectrophysiologic Techniques, CardiacFemaleHeart AtriaHumansHypertensionMaleMiddle AgedPhlebographyPredictive Value of Testsatrial fibrillationatriumhypertensionpulmonary veinsremodeling

Identifiers

PMID25237045
PMCPMC4323835
OpenAlexW2106279355

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.