Evidence map›Paper›PMID 25236972›Full record

ReviewClinical science (London, England : 1979)2015

Pericytes at the intersection between tissue regeneration and pathology.

Alexander Birbrair, Tan Zhang, Zhong-Min Wang, Maria Laura Messi, Akiva Mintz, Osvaldo Delbono

Abstract readReview
In one paragraph

Review in Clinical science (London, England : 1979), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Mechanisms of Pericyte-Mediated Cancer Metastasis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
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66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alexander Birbrair
Tan Zhang*Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
Zhong-Min Wang*Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
Maria Laura Messi*Department of Internal Medicine-Gerontology, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
Akiva Mintz‡Department of Neurosurgery, Wake Forest School of Medicine, Winston-Salem, North Carolina, Medical Center Boulevard, Winston Salem, NC 27157, U.S.A.
Osvaldo Delbono

Funding

Tumor Tissue CoreP30CA012197 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Ruben A. Mesa · 1985 to 2026
$55.4M
Wake Forest Claude D. Pepper OAIC - RenewalP30AG021332 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI Denise Kathryn Houston · 2002 to 2026
$36.4M
Tropin T and Excitation-Contraction Coupling in Aging Skeletal MuscleR01AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 2001 to 2017
$4.7M
Age-Dependent Regulation of Excitation-Contraction CouplingR01AG015820 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 1998 to 2013
$3.4M
Therapeutically Exploiting a Newly Isolated Neural-Like Stem Cell Against GSBR01CA179072 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MINTZ, AKIVA · 2015 to 2020
$1.6M
SINGLE SKETETAL MUSCLE FIBER IMPAIRMENT WITH AGINGR29AG013934 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI DELBONO, OSVALDO · 1997 to 2000
$104k
NCI NIH HHS P30 CA012197NCI NIH HHS R01 CA179072NIA NIH HHS AG13934NIA NIH HHS AG15820NIA NIH HHS P30 AG021332NIA NIH HHS P30-AG21332NIA NIH HHS R01 AG013934NIA NIH HHS R01 AG015820
6 · The paper itself

Abstract

Perivascular multipotent cells, pericytes, contribute to the generation and repair of various tissues in response to injury. They are heterogeneous in their morphology, distribution, origin and markers, and elucidating their molecular and cellular differences may inform novel treatments for disorders in which tissue regeneration is either impaired or excessive. Moreover, these discoveries offer novel cellular targets for therapeutic approaches to many diseases. This review discusses recent studies that support the concept that pericyte subtypes play a distinctive role in myogenesis, neurogenesis, adipogenesis, fibrogenesis and angiogenesis.

Indexed as

RegenerationWound HealingAdipogenesisAge FactorsAgingFibrosisHumansMuscle DevelopmentNeovascularization, PhysiologicNeurogenesisPericytes

Identifiers

PMID25236972
PMCPMC4200531

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.