ReviewCurrent hypertension reports2014
Deep brain stimulation for the treatment of resistant hypertension.
Review in Current hypertension reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed, 28 citations in OpenAlex.
- Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system.Nature reviews. Cardiology · 2026Review
- Neuroprosthetic closed-loop strategy for sustained blood pressure reduction via simultaneous stimulation and recording from the spinal cord.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2025Article
- Glutamate receptors within the lateral periaqueductal gray (lPAG): Effects on blood pressure and heart rate in basic and hypotensive hemorrhagic rats.Iranian journal of basic medical sciences · 2025Article
- Long-term blood pressure outcomes of laparoscopic adrenalectomy in trHTN patients.Journal of translational internal medicine · 2023Article
- Editorial: Cardiovascular neuromodulation: mechanisms and therapies.Frontiers in cardiovascular medicine · 2023Article
- Spinal Reflex Control of Arterial Blood Pressure: The Role of TRP Channels and Their Endogenous Eicosanoid Modulators.Frontiers in physiology · 2022Review
- Cellular and circuit diversity determines the impact of endogenous opioids in the descending pain modulatory pathway.Frontiers in systems neuroscience · 2022Review
- Neuronal Networks in Hypertension: Recent Advances.Hypertension (Dallas, Tex. : 1979) · 2020Review
- Is the Brain an Early or Late Component of Essential Hypertension?American journal of hypertension · 2020Review
- Potential Deep Brain Stimulation Targets for the Management of Refractory Hypertension.Frontiers in neuroscience · 2019Review
- Cortical Structures Associated With Human Blood Pressure Control.JAMA neurology · 2018Article
- Interventional procedures and future drug therapy for hypertension.European heart journal · 2017Review
- Effects of Deep Brain Stimulation on Autonomic Function.Brain sciences · 2016Review
- Microelectrode Guided Implantation of Electrodes into the Subthalamic Nucleus of Rats for Long-term Deep Brain Stimulation.Journal of visualized experiments : JoVE · 2015Article
- [Interventional strategies in hypertension management].Der Internist · 2015Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Hypertension is a leading risk factor for the development of several cardiovascular diseases. As the global prevalence of hypertension increases, so too has the recognition of resistant hypertension. Whilst figures vary, the proportion of hypertensive patients that are resistant to multiple drug therapies have been reported to be as high as 16.4 %. Resistant hypertension is typically associated with elevated sympathetic activity and abnormal homeostatic reflex control and is termed neurogenic hypertension because of its presumed central autonomic nervous system origin. This resistance to conventional pharmacological treatment has stimulated a plethora of medical devices to be investigated for use in hypertension, with varying degrees of success. In this review, we discuss a new therapy for drug-resistant hypertension, deep brain stimulation. The utility of deep brain stimulation in resistant hypertension was first discovered in patients with concurrent neuropathic pain, where it lowered blood pressure and improved baroreflex sensitivity. The most promising central target for stimulation is the ventrolateral periaqueductal gray, which has been well characterised in animal studies as a control centre for autonomic outflow. In this review, we will discuss the promise and potential mechanisms of deep brain stimulation in the treatment of severe, resistant hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.