ArticleAdvances in neurobiology
Ca(2+) signaling in astrocytes and its role in ischemic stroke.
Article in Advances in neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 32 citations in OpenAlex.
- Adolescent alcohol exposure disrupts astrocyte-synaptic structural and functional coupling in the male dorsal hippocampus.Molecular psychiatry · 2026Article
- Dynamic Neuro-Glial-Vascular Responses in a Mouse Model of Vascular Cognitive Impairment.Neuroglia (Basel, Switzerland) · 2024Article
- Astrocyte Regulation of Neuronal Function and Survival in Stroke Pathophysiology.Advances in neurobiology · 2024Review
- Microfluidic Model to Evaluate Astrocyte Activation in Penumbral Region following Ischemic Stroke.Cells · 2022Article
- Role of uroguanylin's signalling pathway in the development of ischaemic stroke.The European journal of neuroscience · 2022Article
- Transcranial magnetic stimulation in animal models of neurodegeneration.Neural regeneration research · 2022Review
- Review
- Endogenous neuroprotective mechanism of ATP2B1 in transcriptional regulation of ischemic preconditioning.American journal of translational research · 2021Article
- Diversity of Reactive Astrogliosis in CNS Pathology: Heterogeneity or Plasticity?Frontiers in cellular neuroscience · 2021Review
- Glutamate Transporters and Mitochondria: Signaling, Co-compartmentalization, Functional Coupling, and Future Directions.Neurochemical research · 2020Review
- Stroke and the neurovascular unit: glial cells, sex differences, and hypertension.American journal of physiology. Cell physiology · 2019Article
- Effect of Inflammation on the Process of Stroke Rehabilitation and Poststroke Depression.Frontiers in psychiatry · 2019Review
- Brain Functional Reserve in the Context of Neuroplasticity after Stroke.Neural plasticity · 2019Review
- Astrocytes Protect Neurons in the Hippocampal CA3 Against Ischemia by Suppressing the Intracellular CaFrontiers in cellular neuroscience · 2018Article
- Reactive astrocytes and therapeutic potential in focal ischemic stroke.Neurobiology of disease · 2016Review
- Dynamic reactive astrocytes after focal ischemia.Neural regeneration research · 2014Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Astrocytes have been found to play important roles in physiology being fundamental for ionic homeostasis and glutamate clearance from the synaptic cleft by their plasma membrane glutamate transporters. Astrocytes are electrically non-excitable, but they exhibit Ca(2+) signaling, which now has been demonstrated to serve as an indirect mediator of neuron-glia bidirectional interactions through gliotransmission via tripartite synapses and to modulate synaptic function and plasticity. Spontaneous astrocytic Ca(2+) signaling was observed in vivo. Intercellular Ca(2+) waves in astrocytes can be evoked by a variety of stimulations. Astrocytes are critically involved in many pathological conditions including ischemic stroke. For example, it is well known that astrocytes become reactive and form glial scar after stroke. In animal models of some brain disorders, astrocytes have been shown to exhibit enhanced Ca(2+) excitability featured as regenerative intercellular Ca(2+) waves. This chapter briefly summarizes astrocytic Ca(2+) signaling pathways under normal conditions and in experimental in vitro and in vivo ischemic models. It discusses the possible mechanisms and therapeutic implication underlying the enhanced astrocytic Ca(2+) excitability in stroke.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.