ArticleIntensive care medicine2014
Temporal trends in critical events complicating HIV infection: 1999-2010 multicentre cohort study in France.
Article in Intensive care medicine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 57 citations in OpenAlex.
- Predictors of 6-month health utility outcomes in survivors of acute respiratory distress syndrome.Thorax · 2017Trial
- Social Precariousness and the Outcome of Critical Illnesses in People with HIV: A Multicenter Cohort Study.Open forum infectious diseases · 2025Article
- Significant Mortality Reduction from SeverePathogens (Basel, Switzerland) · 2025Article
- Outcomes and risk factors in HIV-positive patients with sepsis: a retrospective study.European journal of medical research · 2025Article
- Epidemiological changes and outcomes of people living with HIV admitted to the intensive care unit: a 14-year retrospective study.Infection · 2025Observational
- Comparing short-term mortality between people with and without HIV admitted to the intensive care unit: A single-centre matched cohort study (2000-2019).HIV medicine · 2025Article
- What intensivists need to know about cytomegalovirus infection in immunocompromised ICU patients.Intensive care medicine · 2025Review
- AIDS but not non-AIDS HIV status is associated with mortality in the intensive care unit.Intensive care medicine · 2024Article
- Managing Modern Antiretroviral Therapy in the Intensive Care Unit: Overcoming Challenges for Critically Ill People With Human Immunodeficiency Virus.Open forum infectious diseases · 2024Review
- People living with HIV, HCV and HIV/HCV coinfection in intensive care in a German tertiary referral center 2014-2019.Infection · 2023Article
- Clinical spectrum and prognostic impact of cancer in critically ill patients with HIV: a multicentre cohort study.Annals of intensive care · 2023Article
- Update on the management of patients with HIV infection in anaesthesia and critical care.BJA education · 2023Review
- Outcomes in critically Ill HIV-infected patients between 1997 and 2020: analysis of the OUTCOMEREA multicenter cohort.Critical care (London, England) · 2023Article
- Pulmonary Infections and Outcomes in AIDS Patients with Respiratory Failure: A 10-Year Retrospective Review.Infection and drug resistance · 2023Article
- Study on Respiratory Function and Hemodynamics of AIDS Patients with Respiratory Failure.Infection and drug resistance · 2023Article
- Influence of immunosuppression in patients with severe acute respiratory distress syndrome on veno-venous extracorporeal membrane oxygenation therapy.Artificial organs · 2021Article
- Management of HIV-infected patients in the intensive care unit.Intensive care medicine · 2020Review
- Respiratory virus-associated infections in HIV-infected adults admitted to the intensive care unit for acute respiratory failure: a 6-year bicenter retrospective study (Annals of intensive care · 2020Article
- Six-Month Outcome of Immunocompromised Patients with Severe Acute Respiratory Distress Syndrome Rescued by Extracorporeal Membrane Oxygenation. An International Multicenter Retrospective Study.American journal of respiratory and critical care medicine · 2018Article
- Impact of HIV infection on the presentation, outcome and host response in patients admitted to the intensive care unit with sepsis; a case control study.Critical care (London, England) · 2016Observational
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeMulticentre data are limited to appraise the management and prognosis of critically ill human immunodeficiency virus (HIV)-infected patients. We sought to describe temporal trends in demographic and clinical characteristics, indications for intensive care and outcome in this patient population.
methodsWe conducted a cohort study of unselected HIV-infected patients admitted between 1999 and 2010 to 34 French ICUs contributing to the CUB-Réa prospective database.
resultsWe included 6,373 consecutive patients. Over the 12-year period, increases occurred in median age (39 years in 1999-2001; 47 years in 2008-2010, p < 0.0001) and prevalence of comorbidities (notably malignancies, from 6.7 to 16.4%, p < 0.0001). Admissions for respiratory failure (39.8% overall), shock (8.1%) and coma (22.7%) decreased (p < 0.0001), while those for sepsis (19.3%) remained stable. The main final diagnoses were bacterial sepsis (24.6%) and non-bacterial acquired immune deficiency syndrome (AIDS)-defining diseases (steady decline from 26.0 to 17.5%, p < 0.0001). Patients increasingly received mechanical ventilation (from 42.9 to 54.0%) and renal replacement therapy (from 9.6 to 16.8%) (p < 0.0001), whereas vasopressor use remained stable (27.4%). ICU readmissions increased after 2004 (p < 0.0001). ICU and hospital mortality (17.6 and 26.9%, respectively) dropped markedly in the most severely ill patients requiring multiple life-sustaining therapies. Malignancies and chronic liver disease were heavily associated with hospital mortality by multivariate analysis, while the most common AIDS-defining complications (Pneumocystis jirovecii pneumonia, cerebral toxoplasmosis and tuberculosis) had no independent impact.
conclusionsProgressive ageing, increasing prevalence of comorbidities (mainly malignancies), a steady decline in AIDS-related illnesses and improved benefits from life-sustaining therapies were the main temporal trends in HIV-infected patients requiring ICU admission.
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