ArticleJournal of the American College of Cardiology2014
Impact of lifelong exercise "dose" on left ventricular compliance and distensibility.
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04281264 (Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly), which is not on this map. Cited by 88 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Strength Training in Hypoxia to Improve Bone and Cardiovascular Health of Elderly
Who cites it
88 citing papers in PubMed, 4 syntheses or guidelines pooled it, 243 citations in OpenAlex.
- 2022 ACC Expert Consensus Decision Pathway on Cardiovascular Sequelae of COVID-19 in Adults: Myocarditis and Other Myocardial Involvement, Post-Acute Sequelae of SARS-CoV-2 Infection, and Return to Play: A Report of the American College of Cardiology Solution Set Oversight Committee.Journal of the American College of Cardiology · 2022Guideline
- Effects of exercise training in heart failure with preserved ejection fraction: an updated systematic literature review.Heart failure reviews · 2020Pooled it
- Physiological Responses to Heat Acclimation: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.Journal of sports science & medicine · 2019Pooled it
- Aerobic Training Protects Cardiac Function During Advancing Age: A Meta-Analysis of Four Decades of Controlled Studies.Sports medicine (Auckland, N.Z.) · 2019Pooled it
- Trial
- Trial
- Association between self-reported physical activity and incident atrial fibrillation in a young Korean population.Scientific reports · 2019Trial
- The impact of 2 years of high-intensity exercise training on a model of integrated cardiovascular regulation.The Journal of physiology · 2019Trial
- Reversing the Cardiac Effects of Sedentary Aging in Middle Age-A Randomized Controlled Trial: Implications For Heart Failure Prevention.Circulation · 2018Trial
- The effect of 1 year of Alagebrium and moderate-intensity exercise training on left ventricular function during exercise in seniors: a randomized controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2016Trial
- Cardiac troponin T and echocardiographic dimensions after repeated sprint vs. moderate intensity continuous exercise in healthy young males.Scientific reports · 2016Trial
- Association Between Self-Reported Weekly Physical Activity Duration and Echocardiographic Cardiac Structure and Function in Adults Aged ≥ 45 Years: A Cross-Sectional Study.Journal of cardiovascular development and disease · 2026Article
- Influence of sex and heart size on cardiovascular adaptations to 2 years of endurance exercise training in sedentary middle-aged adults.The Journal of physiology · 2026Article
- The structural and functional aspects of exercise-induced cardiac remodeling and the impact of exercise on cardiovascular outcomes.Annals of medicine · 2025Review
- Influence of Endurance Training, High-Intensity Interval Training, and Acute Exercise on Left Ventricular Mechanics: A Systematic Review.Journal of clinical medicine · 2025Review
- Plasticity of the heart in response to changes in physical activity.The Journal of physiology · 2025Review
- Exercise echocardiography for improved assessment of diastolic filling dynamics.Experimental physiology · 2025Article
- Persistent Fibrosis and Left Ventricular Chamber Stiffening Despite Cessation of Repetitive Pressure Overload in Swine.JACC. Basic to translational science · 2025Article
- Long-term cardiac MRI follow up of MANTICORE (Multidisciplinary Approach to Novel Therapies in Cardio-Oncology REsearch).Cardio-oncology (London, England) · 2025Article
- Different Intensities of Exercise and Cardiovascular Performance: A Review : Different Intensities of Exercise and pCardiovascular Performance.Galen medical journal · 2025Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
backgroundSedentary aging has deleterious effects on the cardiovascular system, including decreased left ventricular compliance and distensibility (LVCD). Conversely, Masters level athletes, who train intensively throughout adulthood, retain youthful LVCD.
objectivesThe purpose of this study was to test the hypothesis that preservation of LVCD may be possible with moderate lifelong exercise training.
methodsHealthy seniors (n = 102) were recruited from predefined populations, screened for lifelong patterns of exercise training, and stratified into 4 groups: "sedentary" (<2 sessions/week); "casual" (2 to 3 sessions/week); "committed" (4 to 5 sessions/week); and "competitive" Masters level athletes (6 to 7 sessions/week). Right heart catheterization and echocardiography were performed while preload was manipulated using lower body negative pressure and rapid saline infusion to define LV pressure-volume relationships and Frank-Starling curves.
resultsPeak oxygen uptake and LV mass increased with escalating doses of lifelong exercise, with little change in systolic function. At baseline, LV distensibility was greater in committed (21%) and competitive (36%) exercisers than in sedentary subjects. Group LV stiffness constants (sedentary: 0.062 ± 0.039; casual: 0.079 ± 0.052; committed: 0.055 ± 0.033; and competitive: 0.035 ± 0.033) revealed: 1) increased stiffness in sedentary subjects compared to competitive athletes, whereas lifelong casual exercise had no effect; and 2) greater compliance in committed exercisers than in sedentary or casual exercisers.
conclusionsLow doses of casual, lifelong exercise do not prevent the decreased compliance and distensibility observed with healthy, sedentary aging. In contrast, 4 to 5 exercise sessions/week throughout adulthood prevent most of these age-related changes. As LV stiffening has been implicated in the pathophysiology of many cardiovascular conditions affecting the elderly, this "dose" of exercise training may have important implications for prevention of cardiovascular disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.