ArticleJournal of the American College of Cardiology2014
Effects of cardiorespiratory fitness on blood pressure trajectory with aging in a cohort of healthy men.
Article in Journal of the American College of Cardiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 107 citations in OpenAlex.
- The effects of a 12-week jump rope exercise program on abdominal adiposity, vasoactive substances, inflammation, and vascular function in adolescent girls with prehypertension.European journal of applied physiology · 2019Trial
- Training in ChiRunning to reduce blood pressure: a randomized controlled pilot study.BMC complementary and alternative medicine · 2015Trial
- Association between cumulative blood pressure and the risk of cognitive impairment in Chinese older adults: a longitudinal study over 16 years.BMC geriatrics · 2025Article
- Assessing the impact of insulin resistance trajectories on cardiovascular disease risk using longitudinal targeted maximum likelihood estimation.Cardiovascular diabetology · 2025Article
- Trajectories of triglyceride-glucose index changes and their association with all-cause and cardiovascular mortality: a competing risk analysis.Cardiovascular diabetology · 2024Article
- Association between untreated and treated blood pressure levels and cognitive decline in community-dwelling middle-aged and older adults in China: a longitudinal study.Alzheimer's research & therapy · 2024Article
- The effect of cardiorespiratory fitness and habitual physical activity on cardiovascular responses to 2 h of uninterrupted sitting.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Cardiorespiratory Fitness and Health Outcomes Across the Spectra of Age, Gender, and Race.Reviews in cardiovascular medicine · 2024Article
- Exercise blood pressure, cardiorespiratory fitness, fatness and cardiovascular risk in children and adolescents.Frontiers in public health · 2024Review
- Endothelin-1 axes in the framework of predictive, preventive and personalised (3P) medicine.The EPMA journal · 2021Review
- Blood Pressure Trajectories Across the Life Course.American journal of hypertension · 2021Article
- Heart Disease and Stroke Statistics-2021 Update: A Report From the American Heart Association.Circulation · 2021Article
- The influence of fitness on exercise blood pressure and its association with cardiac structure in adolescence.Scandinavian journal of medicine & science in sports · 2020Observational
- Brazilian Cardiovascular Rehabilitation Guideline - 2020.Arquivos brasileiros de cardiologia · 2020Article
- Selection of endurance capabilities and the trade-off between pressure and volume in the evolution of the human heart.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Influence of Vigorous Physical Activity on Structure and Function of the Cardiovascular System in Young Athletes-The MuCAYA-Study.Frontiers in cardiovascular medicine · 2019Article
- Combined association of cardiorespiratory fitness and family history of hypertension on the incidence of hypertension: a long-term cohort study of Japanese males.Hypertension research : official journal of the Japanese Society of Hypertension · 2018Article
- Prediction of Prehypertenison and Hypertension Based on Anthropometry, Blood Parameters, and Spirometry.International journal of environmental research and public health · 2018Article
- Improvements in fitness are not obligatory for exercise training-induced improvements in CV risk factors.Physiological reports · 2018Article
- The relationship between obesity and hypertension: an updated comprehensive overview on vicious twins.Hypertension research : official journal of the Japanese Society of Hypertension · 2017Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundAlthough the trajectory of blood pressure (BP) with aging is well known, there is a lack of data on how cardiorespiratory fitness (hereafter referred to as fitness) affects age-associated changes in BP.
objectivesThe objective of the study was to investigate whether fitness alters the aging-BP trajectory.
methodsA cohort from the Aerobics Center Longitudinal Study totaling 13,953 men between 20 and 90 years of age who did not have hypertension, cardiovascular disease, or cancer completed 3 to 28 (mean of 3.8) follow-up medical examinations between 1970 and 2006. Fitness was measured by a maximal treadmill exercise test. Longitudinal data were analyzed using linear mixed models.
resultsDiastolic blood pressure (DBP) tended to increase until nearly 60 years of age, when a decrease was observed. Systolic blood pressure (SBP) tended to increase over all age periods. On multivariate analysis, average SBP increased by 0.30 mm Hg (95% confidence interval: 0.29 to 0.31) with 1-year age increment after adjusting for body fat percent, fitness, resting heart rate, glucose level, triglyceride level, cholesterol level, current smoking, heavy alcohol consumption, and parental history of hypertension. DBP had a yearly increase of 0.14 mm Hg (95% confidence interval: 0.13 to 0.15) before age 60 years. Overall, abnormal SBP (>120 mm Hg) began to occur at approximately 50 years of age and abnormal DBP (>80 mm Hg) began to occur at 60 years of age. Men with higher fitness levels experienced abnormal SBP later than those with low fitness levels.
conclusionsOur findings underscore the potential modifying effect of fitness on BP trajectory with aging over the male adult life span. Improving fitness levels might extend the normal SBP and DBP ranges, delaying the development of hypertension.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.